Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome

Maiken Højgaard Pedersen, C. Mølgaard, Lars Hellgren, L. Lauritzen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    OBJECTIVE: To investigate whether fish oil affects cardiovascular risk factors during the adolescent growth spurt. STUDY DESIGN: A total of 78 boys age 13-15 years with a mean body fat percentage of 30% +/- 9% were randomly assigned to consume fish oil (providing 1.5 g of n-3 long-chain polyunsaturated fatty acid/day) or vegetable oil (control) for 16 weeks. The oils were included in bread. RESULTS: After the intervention, the red blood cell (RBC) content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were 1.2% +/- 0.5% and 6.7% +/- 1.6%, respectively, in the those receiving fish oil (FO group), compared with 0.6% +/- 0.3% and 4.1% +/- 0.9% in the control group. Systolic blood pressure (SBP) was 3.8 +/- 1.4 mm Hg lower (P <.006) and diastolic blood pressure (DBP) was 2.6 +/- 1.1 mm Hg lower (P <.01) in the FO group compared with the control group. Plasma triacylglycerol (TAG) concentration and insulin sensitivity were unaffected by either of the treatments. Plasma high-density lipoprotein (HDL) and non-HDL cholesterol were increased by 5% and 7%, respectively, in the FO group, and by 2% and 0% in the control group (P <.01-.02). The changes in RBC EPA content were inversely correlated with the changes in SBP and DBP and directly correlated with the increases in HDL cholesterol and non-HDL cholesterol concentrations. No association was seen between RBC EPA and plasma TAG concentration or insulin sensitivity. CONCLUSION: Fish oil improves BP in normotensive and normolipidemic slightly overweight adolescent boys. Copyright © 2010 Mosby, Inc. All rights reserved.
    Original languageEnglish
    JournalJournal of Pediatrics
    Volume157
    Issue number3
    Pages (from-to)395-U72
    ISSN0022-3476
    DOIs
    Publication statusPublished - 2010

    Cite this

    Pedersen, M. H., Mølgaard, C., Hellgren, L., & Lauritzen, L. (2010). Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome. Journal of Pediatrics, 157(3), 395-U72. https://doi.org/10.1016/j.jpeds.2010.04.001
    Pedersen, Maiken Højgaard ; Mølgaard, C. ; Hellgren, Lars ; Lauritzen, L. / Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome. In: Journal of Pediatrics. 2010 ; Vol. 157, No. 3. pp. 395-U72.
    @article{667a0c0210ea4738b9653b7f9c67dfa2,
    title = "Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome",
    abstract = "OBJECTIVE: To investigate whether fish oil affects cardiovascular risk factors during the adolescent growth spurt. STUDY DESIGN: A total of 78 boys age 13-15 years with a mean body fat percentage of 30{\%} +/- 9{\%} were randomly assigned to consume fish oil (providing 1.5 g of n-3 long-chain polyunsaturated fatty acid/day) or vegetable oil (control) for 16 weeks. The oils were included in bread. RESULTS: After the intervention, the red blood cell (RBC) content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were 1.2{\%} +/- 0.5{\%} and 6.7{\%} +/- 1.6{\%}, respectively, in the those receiving fish oil (FO group), compared with 0.6{\%} +/- 0.3{\%} and 4.1{\%} +/- 0.9{\%} in the control group. Systolic blood pressure (SBP) was 3.8 +/- 1.4 mm Hg lower (P <.006) and diastolic blood pressure (DBP) was 2.6 +/- 1.1 mm Hg lower (P <.01) in the FO group compared with the control group. Plasma triacylglycerol (TAG) concentration and insulin sensitivity were unaffected by either of the treatments. Plasma high-density lipoprotein (HDL) and non-HDL cholesterol were increased by 5{\%} and 7{\%}, respectively, in the FO group, and by 2{\%} and 0{\%} in the control group (P <.01-.02). The changes in RBC EPA content were inversely correlated with the changes in SBP and DBP and directly correlated with the increases in HDL cholesterol and non-HDL cholesterol concentrations. No association was seen between RBC EPA and plasma TAG concentration or insulin sensitivity. CONCLUSION: Fish oil improves BP in normotensive and normolipidemic slightly overweight adolescent boys. Copyright {\circledC} 2010 Mosby, Inc. All rights reserved.",
    author = "Pedersen, {Maiken H{\o}jgaard} and C. M{\o}lgaard and Lars Hellgren and L. Lauritzen",
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    doi = "10.1016/j.jpeds.2010.04.001",
    language = "English",
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    Pedersen, MH, Mølgaard, C, Hellgren, L & Lauritzen, L 2010, 'Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome', Journal of Pediatrics, vol. 157, no. 3, pp. 395-U72. https://doi.org/10.1016/j.jpeds.2010.04.001

    Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome. / Pedersen, Maiken Højgaard; Mølgaard, C.; Hellgren, Lars; Lauritzen, L.

    In: Journal of Pediatrics, Vol. 157, No. 3, 2010, p. 395-U72.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Effects of Fish Oil Supplementation on Markers of the Metabolic Syndrome

    AU - Pedersen, Maiken Højgaard

    AU - Mølgaard, C.

    AU - Hellgren, Lars

    AU - Lauritzen, L.

    PY - 2010

    Y1 - 2010

    N2 - OBJECTIVE: To investigate whether fish oil affects cardiovascular risk factors during the adolescent growth spurt. STUDY DESIGN: A total of 78 boys age 13-15 years with a mean body fat percentage of 30% +/- 9% were randomly assigned to consume fish oil (providing 1.5 g of n-3 long-chain polyunsaturated fatty acid/day) or vegetable oil (control) for 16 weeks. The oils were included in bread. RESULTS: After the intervention, the red blood cell (RBC) content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were 1.2% +/- 0.5% and 6.7% +/- 1.6%, respectively, in the those receiving fish oil (FO group), compared with 0.6% +/- 0.3% and 4.1% +/- 0.9% in the control group. Systolic blood pressure (SBP) was 3.8 +/- 1.4 mm Hg lower (P <.006) and diastolic blood pressure (DBP) was 2.6 +/- 1.1 mm Hg lower (P <.01) in the FO group compared with the control group. Plasma triacylglycerol (TAG) concentration and insulin sensitivity were unaffected by either of the treatments. Plasma high-density lipoprotein (HDL) and non-HDL cholesterol were increased by 5% and 7%, respectively, in the FO group, and by 2% and 0% in the control group (P <.01-.02). The changes in RBC EPA content were inversely correlated with the changes in SBP and DBP and directly correlated with the increases in HDL cholesterol and non-HDL cholesterol concentrations. No association was seen between RBC EPA and plasma TAG concentration or insulin sensitivity. CONCLUSION: Fish oil improves BP in normotensive and normolipidemic slightly overweight adolescent boys. Copyright © 2010 Mosby, Inc. All rights reserved.

    AB - OBJECTIVE: To investigate whether fish oil affects cardiovascular risk factors during the adolescent growth spurt. STUDY DESIGN: A total of 78 boys age 13-15 years with a mean body fat percentage of 30% +/- 9% were randomly assigned to consume fish oil (providing 1.5 g of n-3 long-chain polyunsaturated fatty acid/day) or vegetable oil (control) for 16 weeks. The oils were included in bread. RESULTS: After the intervention, the red blood cell (RBC) content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were 1.2% +/- 0.5% and 6.7% +/- 1.6%, respectively, in the those receiving fish oil (FO group), compared with 0.6% +/- 0.3% and 4.1% +/- 0.9% in the control group. Systolic blood pressure (SBP) was 3.8 +/- 1.4 mm Hg lower (P <.006) and diastolic blood pressure (DBP) was 2.6 +/- 1.1 mm Hg lower (P <.01) in the FO group compared with the control group. Plasma triacylglycerol (TAG) concentration and insulin sensitivity were unaffected by either of the treatments. Plasma high-density lipoprotein (HDL) and non-HDL cholesterol were increased by 5% and 7%, respectively, in the FO group, and by 2% and 0% in the control group (P <.01-.02). The changes in RBC EPA content were inversely correlated with the changes in SBP and DBP and directly correlated with the increases in HDL cholesterol and non-HDL cholesterol concentrations. No association was seen between RBC EPA and plasma TAG concentration or insulin sensitivity. CONCLUSION: Fish oil improves BP in normotensive and normolipidemic slightly overweight adolescent boys. Copyright © 2010 Mosby, Inc. All rights reserved.

    U2 - 10.1016/j.jpeds.2010.04.001

    DO - 10.1016/j.jpeds.2010.04.001

    M3 - Journal article

    VL - 157

    SP - 395-U72

    JO - Journal of Pediatrics

    JF - Journal of Pediatrics

    SN - 0022-3476

    IS - 3

    ER -