Effects of azole fungicides on the function of sex and thyroid hormones

Mia Birkhøj Kjærstad; Helle Raun Andersen; Camilla Taxvig; Ulla Hass; Marta Axelstad Petersen; Stine Broeng Metzdorff; Anne Vinggaard

Effects of azole fungicides on the function of sex and thyroid hormones

Mia Birkhøj Kjærstad, Helle Raun Andersen, Camilla Taxvig, Ulla Hass, Marta Axelstad Petersen, Stine Broeng Metzdorff, Anne Vinggaard

National Food Institute

University of Southern Denmark

Research output: Book/Report › Report › Research › peer-review

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Abstract

Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

Original language	English

Publisher	Miljøstyrelsen
Publication status	Published - 2007

Series	Pesticides Research - Report for the Danish EPA
Number	111

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Pesticides Research No 111 2007Final published version, 575 KB

http://www2.mst.dk/Udgiv/publications/2007/978-87-7052-538-1/pdf/978-87-7052-539-8.pdf

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@book{682969e748a3431a9e4534ab315cb866,

title = "Effects of azole fungicides on the function of sex and thyroid hormones",

abstract = "Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.",

author = "Kj{\ae}rstad, {Mia Birkh{\o}j} and Andersen, {Helle Raun} and Camilla Taxvig and Ulla Hass and Petersen, {Marta Axelstad} and Metzdorff, {Stine Broeng} and Anne Vinggaard",

year = "2007",

language = "English",

series = "Pesticides Research - Report for the Danish EPA",

number = "111",

publisher = "Milj{\o}styrelsen",

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TY - RPRT

T1 - Effects of azole fungicides on the function of sex and thyroid hormones

AU - Kjærstad, Mia Birkhøj

AU - Andersen, Helle Raun

AU - Taxvig, Camilla

AU - Hass, Ulla

AU - Petersen, Marta Axelstad

AU - Metzdorff, Stine Broeng

AU - Vinggaard, Anne

PY - 2007

Y1 - 2007

N2 - Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

AB - Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

Effects of azole fungicides on the function of sex and thyroid hormones

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