Effects of azole fungicides on the function of sex and thyroid hormones

Mia Birkhøj Kjærstad, Helle Raun Andersen, Camilla Taxvig, Ulla Hass, Marta Axelstad Petersen, Stine Broeng Metzdorff, Anne Vinggaard

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Abstract

Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring. Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.
Original languageEnglish
PublisherMiljøstyrelsen
Publication statusPublished - 2007
SeriesPesticides Research - Report for the Danish EPA
Number111

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