Effector CD4 and CD8 T cells and their role in the tumor microenvironment

Sine Reker Hadrup, Marco Donia, Per Thor Straten

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

T cells in tumors - the so-called tumor infiltrating lymphocytes (TIL) have been studied intensively over the past years. Compelling evidence point to a clinical relevance for high numbers of T cells at the tumor site with CD8 memory T cells as a key denominator for overall survival (OS) in patients with colo-rectal cancer (CRC), and also for others solid cancers. These data goes hand in hand with studies of clonality of TIL showing the T cells among TIL are expanded clonally, and also that tumor specific T cells of CD4 as well as CD8 type are enriched at the tumor site. The tumor microenvironment is hostile to T cell function e.g., due to expression of enzymes that depletes the amino acids tryptophan and arginine, high concentration of tumor secreted lactate, and presence innate cells or regulatory T cells both with suppressive activity. Analyses of the specificity of TILs in melanoma demonstrate that quite few known antigens are in fact recognized by these cultures underscoring patient unique and/or mutated antigens may represent important target for recognition. �� 2012 The Author(s).
Original languageEnglish
JournalCancer Microenvironment
Volume6
Issue number2
Pages (from-to)123-133
Number of pages11
ISSN1875-2292
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Cancer Research
  • Oncology
  • Cancer
  • Effector T cell
  • Tumor immunology
  • Tumor infiltrating lymphocytes (TIL)
  • cancer vaccine
  • cytotoxic T lymphocyte antigen 4
  • interleukin 2
  • programmed death 1 receptor
  • T lymphocyte receptor
  • adoptive immunotherapy
  • antigen recognition
  • antigen specificity
  • article
  • cancer prognosis
  • cancer survival
  • CD4+ T lymphocyte
  • CD8+ T lymphocyte
  • cell count
  • cell therapy
  • clinical effectiveness
  • cytokine production
  • cytokine release
  • drug megadose
  • head and neck squamous cell carcinoma
  • human
  • immune response
  • immunomodulation
  • immunoregulation
  • Kaposi sarcoma
  • kidney carcinoma
  • lymphocyte function
  • lymphocyte subpopulation
  • lymphocytic infiltration
  • melanoma
  • Merkel cell tumor
  • ovary cancer
  • overall survival
  • phenotype
  • priority journal
  • protein expression
  • treatment response
  • tumor associated leukocyte
  • tumor immunity
  • tumor microenvironment
  • uterine cervix cancer
  • HASH(0x34558f8)

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