Effect of Whole-Body X-Irradiation of the Synthesis of Individual Fatty Acids in Liver Slices from Normal and Fasted Rats

Heinz Johs. Max Hansen, Lisbeth Grænge Hansen, M. Faber

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    (1) Using (2-14C) acetate and (1-14C) butyrate as precursors, rat-liver fatty acids were synthesized in vitro and assayed by paper chromatography. (2) Whole-body x-irradiation induced a change in the synthetic pattern of hepatic fatty acids towards a relatively enhanced synthesis of palmitic acid. (3) X-irradiation and fasting seem to have opposite effects on fatty-acid synthesis. X-irradiation counteracts the drop in total synthesis and the relatively enhanced synthesis of palmitoleic acid induced by fasting. The relative enhancement of palmitic-acid synthesis mentioned under (2) stands in contrast to the effect of fasting, which specifically decreases the hepatic synthesis of palmitic acid. (4) There is a general similarity between corresponding fatty-acid patterns based on synthesis from (2-14C) acetate and (1-14C) butyrate, respectively.
    Original languageEnglish
    JournalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
    Issue number1
    Pages (from-to)25-36
    Publication statusPublished - 1965

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