Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern

Frederik Plesner Lyngse; Kåre Mølbak; Matt Denwood; Lasse Engbo Christiansen; Camilla Holten Møller; Morten Rasmussen; Arieh Sierra Cohen; Marc Stegger; Jannik Fonager; Raphael Niklaus Sieber; Kirsten Maren Ellegaard; Claus Nielsen; Carsten Thure Kirkeby

doi:10.1038/s41467-022-31494-y

Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern

Frederik Plesner Lyngse^*
, Kåre Mølbak
, Matt Denwood
, Lasse Engbo Christiansen
, Camilla Holten Møller
, Morten Rasmussen
, Arieh Sierra Cohen
, Marc Stegger
, Jannik Fonager
, Raphael Niklaus Sieber
, Kirsten Maren Ellegaard
, Claus Nielsen
, Carsten Thure Kirkeby

^*Corresponding author for this work

University of Copenhagen
Statens Serum Institut

Research output: Contribution to journal › Journal article › Research › peer-review

58 Downloads (Orbit)

Abstract

Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VE_S) and vaccine effectiveness against infectiousness (VE_I), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VE_S as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VE_I as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.

Original language	English
Article number	3764
Journal	Nature Communications
Volume	13
Issue number	1
Number of pages	8
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-022-31494-y
Publication status	Published - Dec 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/s41467-022-31494-y

FulltextFinal published version, 776 KB

OpenUrl availability

Check availability in DTU Findit

Cite this

Lyngse, F. P., Mølbak, K., Denwood, M., Christiansen, L. E., Møller, C. H., Rasmussen, M., Cohen, A. S., Stegger, M., Fonager, J., Sieber, R. N., Ellegaard, K. M., Nielsen, C., & Kirkeby, C. T. (2022). Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern. Nature Communications, 13(1), Article 3764. https://doi.org/10.1038/s41467-022-31494-y

@article{048b4e9e4942412a8cc1758ac198cc42,

title = "Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern",

abstract = "Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VES) and vaccine effectiveness against infectiousness (VEI), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VES as 61\% (95\%-CI: 59-63), when the primary case was unvaccinated, and VEI as 31\% (95\%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.",

author = "Lyngse, \{Frederik Plesner\} and K{\aa}re M{\o}lbak and Matt Denwood and Christiansen, \{Lasse Engbo\} and M{\o}ller, \{Camilla Holten\} and Morten Rasmussen and Cohen, \{Arieh Sierra\} and Marc Stegger and Jannik Fonager and Sieber, \{Raphael Niklaus\} and Ellegaard, \{Kirsten Maren\} and Claus Nielsen and Kirkeby, \{Carsten Thure\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-31494-y",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern

AU - Lyngse, Frederik Plesner

AU - Mølbak, Kåre

AU - Denwood, Matt

AU - Christiansen, Lasse Engbo

AU - Møller, Camilla Holten

AU - Rasmussen, Morten

AU - Cohen, Arieh Sierra

AU - Stegger, Marc

AU - Fonager, Jannik

AU - Sieber, Raphael Niklaus

AU - Ellegaard, Kirsten Maren

AU - Nielsen, Claus

AU - Kirkeby, Carsten Thure

PY - 2022/12

Y1 - 2022/12

N2 - Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VES) and vaccine effectiveness against infectiousness (VEI), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VES as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VEI as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.

AB - Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VES) and vaccine effectiveness against infectiousness (VEI), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VES as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VEI as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.

U2 - 10.1038/s41467-022-31494-y

DO - 10.1038/s41467-022-31494-y

M3 - Journal article

C2 - 35773247

AN - SCOPUS:85133121692

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 3764

ER -

Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern

Abstract

UN SDGs

Access to Document

OpenUrl availability

Fingerprint

Cite this