Effect of kinetic parameters on heterologous protein production: a sysbio approach

Subir Kumar Nandy; Stig Rattleff; Jette Thykær; Anna Eliasson Lantz

Effect of kinetic parameters on heterologous protein production: a sysbio approach

Subir Kumar Nandy, Stig Rattleff, Jette Thykær, Anna Eliasson Lantz

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Abstract

To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition.

Original language	English
Publication date	2011
Publication status	Published - 2011
Event	6th Danish Conference on Biotechnology and Molecular Biology: Synthetic Biology and Cell Factories - Vejle, Denmark Duration: 26 May 2011 → 27 May 2011 Conference number: 6

Conference

Conference	6th Danish Conference on Biotechnology and Molecular Biology
Number	6
Country/Territory	Denmark
City	Vejle
Period	26/05/2011 → 27/05/2011

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SUBIR DTU annual meeting Vejle2011 posterFinal published version, 416 KB

http://www.biokemi.org/meetings/56

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title = "Effect of kinetic parameters on heterologous protein production: a sysbio approach",

abstract = "To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition.",

author = "Nandy, {Subir Kumar} and Stig Rattleff and Jette Thyk{\ae}r and {Eliasson Lantz}, Anna",

year = "2011",

language = "English",

note = "6th Danish Conference on Biotechnology and Molecular Biology : Synthetic Biology and Cell Factories ; Conference date: 26-05-2011 Through 27-05-2011",

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TY - CONF

T1 - Effect of kinetic parameters on heterologous protein production: a sysbio approach

AU - Nandy, Subir Kumar

AU - Rattleff, Stig

AU - Thykær, Jette

AU - Eliasson Lantz, Anna

N1 - Conference code: 6

PY - 2011

Y1 - 2011

N2 - To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition.

AB - To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition.

M3 - Poster

T2 - 6th Danish Conference on Biotechnology and Molecular Biology

Y2 - 26 May 2011 through 27 May 2011

ER -

Effect of kinetic parameters on heterologous protein production: a sysbio approach

Abstract

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