Effect of kinetic parameters on heterologous protein production: a sysbio approach

Subir Kumar Nandy, Stig Rattleff, Jette Thykær, Anna Eliasson Lantz

    Research output: Contribution to conferencePosterResearchpeer-review

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    Abstract

    To improve the expression and secretion of heterologous proteins in the filamentous grampositive bacteria, Streptomyces lividans, bioprocessing strategies were developed. A mathematical model was constructed to study the effects of the process kinetic parameters on the production of the model-protein RFP. The model describes the dynamics of glucose consumption and formation of biomass in addition to RFP production. The model was also extended to describe a two substrate condition.
    Original languageEnglish
    Publication date2011
    Publication statusPublished - 2011
    Event6th Danish Conference on Biotechnology and Molecular Biology: Synthetic Biology and Cell Factories - Vejle, Denmark
    Duration: 26 May 201127 May 2011
    Conference number: 6

    Conference

    Conference6th Danish Conference on Biotechnology and Molecular Biology
    Number6
    CountryDenmark
    CityVejle
    Period26/05/201127/05/2011

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