Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

T. Tholstrup, G.J. Miller, Anette Bysted, B. Sandstrom

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation. Objective: We tested the hypothesis that FVII activation would be less after consumption of saturated fatty acids than after other fatty acids. Design: The effects of 6 matching dietary test fats, rich in stearic (S), palmitic (P), palmitic + myristic (M), oleic (O), trans 18:1 (T), and linoleic (L) acid, respectively, on the postprandial lipid and hemostatic profile (after 2, 4, 6, and 8 h) were investigated in 16 young men. High-fat meals (1 g fat/kg body wt; 43% from the test fatty acid) were served in the morning on 6 separate days. Results: All fats increased FVII activation. The S fat resulted in a lower increase in activated, FVII (FVIIa) than did the T fat and in a lower FVII coagulant activity (FVII:c) than did the 0 fat (P <0.02, diet X time interaction). When the data were pooled, the saturated (S, P, and M) test fats resulted in a smaller postprandial increase in FVIIa (P = 0.036, diet effect), a smaller increase in FVII:c (P <0.001, diet X time interaction), a greater rise in tissue plasminogen activator concentrations (P = 0.028, diet effect), and a tendency to a greater postprandial decline in PAI-1 (P = 0.06, diet effect) compared with the unsaturated test fats (O, T, and L). The increase in FVIIa was not significantly associated with the level of lipemia, plasma FFAs, or plasma lipoprotein lipase activity. Conclusion: Our results indicate a lesser increase in FVIIa after the consumption of saturated fats, especially the S fat, than after unsaturated test fats.
Original languageEnglish
JournalAMERICAN JOURNAL OF CLINICAL NUTRITION
Volume77
Issue number5
Pages (from-to)1125-1132
ISSN0002-9165
Publication statusPublished - May 2003

Keywords

  • factor VII
  • plasminogen activator inhibitor type 1
  • PAI-1
  • tissue plasminogen activator
  • stearic acid
  • saturated fatty acids
  • unsaturated fatty acids
  • postprandial lipemia
  • men

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