Abstract
| Original language | English |
|---|---|
| Journal | Chemical Engineering Journal |
| Volume | 347 |
| Pages (from-to) | 525-534 |
| ISSN | 1385-8947 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- HRT
- Continuous fermentation
- Statistical optimization
- Joint production
- Mixed microbial consortia
- 2G crude glycerol
Cite this
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Effect of hydraulic retention time on the modelling and optimization of joint 1,3 PDO and BuA production from 2G glycerol in a chemostat process. / Varrone, Cristiano; Skiadas, Ioannis V.; Gavala, Hariklia N.
In: Chemical Engineering Journal, Vol. 347, 2018, p. 525-534.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - Effect of hydraulic retention time on the modelling and optimization of joint 1,3 PDO and BuA production from 2G glycerol in a chemostat process
AU - Varrone, Cristiano
AU - Skiadas, Ioannis V.
AU - Gavala, Hariklia N.
PY - 2018
Y1 - 2018
N2 - This study investigated the possibility to perform statistical optimization of an enriched mixed microbial consortium, MMC, fed in continuous with a highly inhibiting 2G glycerol, for the joint production of 1,3 propanediol (1,3 PDO) and butyric acid (BuA). Key variables taken into consideration were HRT, pH and feed concentration. The optimized process reached a glycerol consumption rate of 137 g/L/d and a maximum predicted production rate of 82.61 g/L/d and 21.13 g/L/d for 1,3 PDO and BuA, respectively. This corresponded to a 2.2 and 1.9-fold increase compared to the non-optimized process. The model was able to satisfactorily predict the joint maximum production of 1,3 PDO and BuA (22.6 and 8.1 g/L respectively) of the steady state also in non-sterile conditions, implying thus that MMC can be a robust and reliable biological production platform.
AB - This study investigated the possibility to perform statistical optimization of an enriched mixed microbial consortium, MMC, fed in continuous with a highly inhibiting 2G glycerol, for the joint production of 1,3 propanediol (1,3 PDO) and butyric acid (BuA). Key variables taken into consideration were HRT, pH and feed concentration. The optimized process reached a glycerol consumption rate of 137 g/L/d and a maximum predicted production rate of 82.61 g/L/d and 21.13 g/L/d for 1,3 PDO and BuA, respectively. This corresponded to a 2.2 and 1.9-fold increase compared to the non-optimized process. The model was able to satisfactorily predict the joint maximum production of 1,3 PDO and BuA (22.6 and 8.1 g/L respectively) of the steady state also in non-sterile conditions, implying thus that MMC can be a robust and reliable biological production platform.
KW - HRT
KW - Continuous fermentation
KW - Statistical optimization
KW - Joint production
KW - Mixed microbial consortia
KW - 2G crude glycerol
U2 - 10.1016/j.cej.2018.04.071
DO - 10.1016/j.cej.2018.04.071
M3 - Journal article
VL - 347
SP - 525
EP - 534
JO - Biochemical Engineering Journal
JF - Biochemical Engineering Journal
SN - 1369-703X
ER -