Effect of gamma irradiation on the physicochemical and rheological properties of enzyme-catalyzed tragacanth-based injectable hydrogels

Moslem Tavakol*, Ebrahim Vasheghani-Farahani, Mohammad Amin Mohammadifar, Maryam Dehghan-Niri

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In the present study, gamma irradiation was applied to promote the mechanical properties of enzyme-mediated in situ forming hydrogels prepared with tyramine-functionalized gum tragacanth (TA-GT). For this purpose, after gamma irradiation of powder or hydrocolloid solution of gum tragacanth (GT), the physiochemical and rheological properties of GT solution, and resultant hydrogel was investigated. In situ forming hydrogels were prepared via horseradish peroxidase catalyzed coupling reaction of TA-GT in the presence of hydrogen peroxide. Gamma irradiation led to a decrease in GT molecular weight and solution viscosity. Also, the solubility of GT improved and the separation of water soluble/swellable part of gum samples became easier, using gamma irradiation. In addition, by gamma irradiation of GT powder at doses of 5-15 kGy, a polymeric solution with higher concentration could be prepared that resulted in the promotion of hydrogels storage modulus. Further increase of irradiation dose did not improve storage modulus due to the extra decrease of gum molecular weight.
Original languageEnglish
JournalJournal of Polymer Engineering
Volume39
Issue number5
Pages (from-to)442-449
ISSN0334-6447
DOIs
Publication statusPublished - 2019

Keywords

  • Gamma irradiation
  • Injectable hydrogel
  • Physiochemical properties
  • Rheological properties
  • Tragacanth

Cite this

@article{595e38076f8544e3895dcbd69dff4605,
title = "Effect of gamma irradiation on the physicochemical and rheological properties of enzyme-catalyzed tragacanth-based injectable hydrogels",
abstract = "In the present study, gamma irradiation was applied to promote the mechanical properties of enzyme-mediated in situ forming hydrogels prepared with tyramine-functionalized gum tragacanth (TA-GT). For this purpose, after gamma irradiation of powder or hydrocolloid solution of gum tragacanth (GT), the physiochemical and rheological properties of GT solution, and resultant hydrogel was investigated. In situ forming hydrogels were prepared via horseradish peroxidase catalyzed coupling reaction of TA-GT in the presence of hydrogen peroxide. Gamma irradiation led to a decrease in GT molecular weight and solution viscosity. Also, the solubility of GT improved and the separation of water soluble/swellable part of gum samples became easier, using gamma irradiation. In addition, by gamma irradiation of GT powder at doses of 5-15 kGy, a polymeric solution with higher concentration could be prepared that resulted in the promotion of hydrogels storage modulus. Further increase of irradiation dose did not improve storage modulus due to the extra decrease of gum molecular weight.",
keywords = "Gamma irradiation, Injectable hydrogel, Physiochemical properties, Rheological properties, Tragacanth",
author = "Moslem Tavakol and Ebrahim Vasheghani-Farahani and Mohammadifar, {Mohammad Amin} and Maryam Dehghan-Niri",
year = "2019",
doi = "10.1515/polyeng-2018-0366",
language = "English",
volume = "39",
pages = "442--449",
journal = "Journal of Polymer Engineering",
issn = "0334-6447",
publisher = "Walterde Gruyter GmbH",
number = "5",

}

Effect of gamma irradiation on the physicochemical and rheological properties of enzyme-catalyzed tragacanth-based injectable hydrogels. / Tavakol, Moslem; Vasheghani-Farahani, Ebrahim; Mohammadifar, Mohammad Amin; Dehghan-Niri, Maryam.

In: Journal of Polymer Engineering, Vol. 39, No. 5, 2019, p. 442-449.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Effect of gamma irradiation on the physicochemical and rheological properties of enzyme-catalyzed tragacanth-based injectable hydrogels

AU - Tavakol, Moslem

AU - Vasheghani-Farahani, Ebrahim

AU - Mohammadifar, Mohammad Amin

AU - Dehghan-Niri, Maryam

PY - 2019

Y1 - 2019

N2 - In the present study, gamma irradiation was applied to promote the mechanical properties of enzyme-mediated in situ forming hydrogels prepared with tyramine-functionalized gum tragacanth (TA-GT). For this purpose, after gamma irradiation of powder or hydrocolloid solution of gum tragacanth (GT), the physiochemical and rheological properties of GT solution, and resultant hydrogel was investigated. In situ forming hydrogels were prepared via horseradish peroxidase catalyzed coupling reaction of TA-GT in the presence of hydrogen peroxide. Gamma irradiation led to a decrease in GT molecular weight and solution viscosity. Also, the solubility of GT improved and the separation of water soluble/swellable part of gum samples became easier, using gamma irradiation. In addition, by gamma irradiation of GT powder at doses of 5-15 kGy, a polymeric solution with higher concentration could be prepared that resulted in the promotion of hydrogels storage modulus. Further increase of irradiation dose did not improve storage modulus due to the extra decrease of gum molecular weight.

AB - In the present study, gamma irradiation was applied to promote the mechanical properties of enzyme-mediated in situ forming hydrogels prepared with tyramine-functionalized gum tragacanth (TA-GT). For this purpose, after gamma irradiation of powder or hydrocolloid solution of gum tragacanth (GT), the physiochemical and rheological properties of GT solution, and resultant hydrogel was investigated. In situ forming hydrogels were prepared via horseradish peroxidase catalyzed coupling reaction of TA-GT in the presence of hydrogen peroxide. Gamma irradiation led to a decrease in GT molecular weight and solution viscosity. Also, the solubility of GT improved and the separation of water soluble/swellable part of gum samples became easier, using gamma irradiation. In addition, by gamma irradiation of GT powder at doses of 5-15 kGy, a polymeric solution with higher concentration could be prepared that resulted in the promotion of hydrogels storage modulus. Further increase of irradiation dose did not improve storage modulus due to the extra decrease of gum molecular weight.

KW - Gamma irradiation

KW - Injectable hydrogel

KW - Physiochemical properties

KW - Rheological properties

KW - Tragacanth

U2 - 10.1515/polyeng-2018-0366

DO - 10.1515/polyeng-2018-0366

M3 - Journal article

VL - 39

SP - 442

EP - 449

JO - Journal of Polymer Engineering

JF - Journal of Polymer Engineering

SN - 0334-6447

IS - 5

ER -