Editorial: 3Rs tightly intertwined to maintain genome stability

Michael Lisby (Editor), Uffe Hasbro Mortensen (Editor)

Research output: Contribution to journalEditorialpeer-review

Abstract

DNA recombination, repair and replication are three large and vibrant research fields where each ‘R’ could deserve a series of reviews in its own right. However, as the 3Rs are tightly interwoven processes, one R can often not be fully understood without including the others. For example, replication of damaged DNA results in stalled replication forks that await DNA damage repair before replication can be resumed. In turn, the repair of most lesions depends on processes involving DNA synthesis. At the same time, the stalled forks may engage in recombination, either as part of a controlled repair process or by accident, just because it can, with the risk of producing genome rearrangements and loss of heterozygosity. The set of reviews presented in this thematic issue (https://academic-oup-com.proxy.findit.dtu.dk/femsyr/pages/replication_recombination_and_repair) of FEMSYR has been selected to highlight the intricate connections between the three Rs.
Original languageEnglish
Article numberfox003
JournalFEMS Yeast Research
Volume17
Issue number1
Number of pages2
ISSN1567-1356
DOIs
Publication statusPublished - 2017

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