EasyCloneYALI: Toolbox for CRISPR-Mediated Integrations and Deletions in Yarrowia lipolytica

Jonathan Dahlin, Carina Holkenbrink, Irina Borodina*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

In order to unlock the full potential of Yarrowia lipolytica, as model organism and production host, simple and reliable tools for genome engineering are essential. In this chapter, the practical details of working with the EasyCloneYALI Toolbox are described.Highlights of the EasyCloneYALI Toolbox are high genome editing efficiencies, multiplexed Cas9-mediated knockouts, targeted genomic integrations into characterized intergenic loci, as well as streamlined and convenient cloning for both marker-based and marker-free integrative expression vectors.
Original languageEnglish
Title of host publicationYarrowia lipolytica
Number of pages28
Volume2307
PublisherSpringer
Publication date2021
Pages41-68
DOIs
Publication statusPublished - 2021
SeriesMethods in Molecular Biology
ISSN1064-3745

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