Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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  • Author: Vindas, Marco A

    Uni Research AS, Norway

  • Author: Fokos, Stefanos

    University of Patras, Greece

  • Author: Pavlidis, Michail

    University of Crete, Greece

  • Author: Höglund, Erik

    Norwegian Institute for Water Research

    Section for Aquaculture, National Institute of Aquatic Resources, Technical University of Denmark, Nordsøen Forskerpark Postboks 101, 9850, Hirtshals, Denmark

  • Author: Dionysopoulou, Sylvia

    University of Patras, Greece

  • Author: Ebbesson, Lars O.E.

    Uni Research AS, Norway

  • Author: Papandroulakis, Nikolaos

    Hellenic Centre for Marine Research, Greece

  • Author: Dermon, Catherine R.

    University of Patras, Greece

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Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.
Original languageEnglish
Article number5638
JournalScientific Reports
Volume8
Issue number1
ISSN2045-2322
DOIs
Publication statusPublished - 2018
CitationsWeb of Science® Times Cited: No match on DOI

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