Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping

Marco A. Vindas*, Stefanos Fokos, Michail Pavlidis, Erik Höglund, Sylvia Dionysopoulou, Lars O. E. Ebbesson, Nikolaos Papandroulakis, Catherine R. Dermon

*Corresponding author for this work

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Abstract

Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.
Original languageEnglish
Article number5638
JournalScientific Reports
Volume8
Issue number1
ISSN2045-2322
DOIs
Publication statusPublished - 2018

Cite this

Vindas, M. A., Fokos, S., Pavlidis, M., Höglund, E., Dionysopoulou, S., Ebbesson, L. O. E., ... Dermon, C. R. (2018). Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping. Scientific Reports, 8(1), [5638]. https://doi.org/10.1038/s41598-018-23950-x
Vindas, Marco A. ; Fokos, Stefanos ; Pavlidis, Michail ; Höglund, Erik ; Dionysopoulou, Sylvia ; Ebbesson, Lars O. E. ; Papandroulakis, Nikolaos ; Dermon, Catherine R. / Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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title = "Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping",
abstract = "Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.",
author = "Vindas, {Marco A.} and Stefanos Fokos and Michail Pavlidis and Erik H{\"o}glund and Sylvia Dionysopoulou and Ebbesson, {Lars O. E.} and Nikolaos Papandroulakis and Dermon, {Catherine R.}",
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Vindas, MA, Fokos, S, Pavlidis, M, Höglund, E, Dionysopoulou, S, Ebbesson, LOE, Papandroulakis, N & Dermon, CR 2018, 'Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping', Scientific Reports, vol. 8, no. 1, 5638. https://doi.org/10.1038/s41598-018-23950-x

Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping. / Vindas, Marco A.; Fokos, Stefanos; Pavlidis, Michail; Höglund, Erik; Dionysopoulou, Sylvia; Ebbesson, Lars O. E.; Papandroulakis, Nikolaos; Dermon, Catherine R.

In: Scientific Reports, Vol. 8, No. 1, 5638, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping

AU - Vindas, Marco A.

AU - Fokos, Stefanos

AU - Pavlidis, Michail

AU - Höglund, Erik

AU - Dionysopoulou, Sylvia

AU - Ebbesson, Lars O. E.

AU - Papandroulakis, Nikolaos

AU - Dermon, Catherine R.

PY - 2018

Y1 - 2018

N2 - Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.

AB - Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented post-acute stress downregulation of the α2Α receptor in the amygdala homologue (Dm3). There was a lack of post-stress response in the β2 adrenergic receptor expression and a downregulation in bdnf in the Dm3 of ELS fish, which together indicate an allostatic overload in their stress coping ability. ELS fish showed higher neuronal activity (cfos) post-acute stress in the hippocampus homologue (Dlv) and the Dm3. Our results show clear long-term effects on limbic systems of seabream that may compromise their future coping ability to environmental challenges.

U2 - 10.1038/s41598-018-23950-x

DO - 10.1038/s41598-018-23950-x

M3 - Journal article

C2 - 29618742

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 5638

ER -