Early Administration of Probiotics Alters Bacterial Colonization and Limits Diet-Induced Gut Dysfunction and Severity of Necrotizing Enterocolitis in Preterm Pigs

Richard H. Siggers, Jayda Siggers, Mette Boye, Thomas Thymann, Lars Mølbak, Thomas Leser, Bent B. Jensen, Per T. Sangild

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Following preterm birth, bacterial colonization and interal formula feeding predispose neonates to gut dysfunction and necrotizing enterocilitis (NEC), a serious gastrointestinal inflammatory disease. We hypothesized that administration of probiotics would beneficially influence early bacterial colonization, thereby reducing the susceptibility to formula-induced gut atrophy, dysfunction, and NEC. Caesarean-delivered preterm pigs were provided total parenteral nutrition (1.5 d) followed by enteral feeding (2d) with porcine colosstrum (COLOS; n= 5), formula (FORM; n = 9), or formula with probiotics (FORM-P, Bifidobacterium animalis and Lactobacillus: L. acidophilus, L. casei, L. pentosus, L. planterum; (n=13). Clinical NEC scores were reduced (P
    Original languageEnglish
    JournalJournal of Nutrition
    Volume138
    Issue number8
    Pages (from-to)1437-1444
    ISSN0022-3166
    Publication statusPublished - 2008

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