Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

D.E. Postnov; R.N. Koreshkov; N.A. Brazhe; A.R. Brazhe; Olga Sosnovtseva

doi:10.1007/s10867-009-9156-x

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

D.E. Postnov, R.N. Koreshkov, N.A. Brazhe, A.R. Brazhe, Olga Sosnovtseva

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

Original language	English
Journal	Journal of Biological Physics
Volume	35
Issue number	4
Pages (from-to)	425-445
ISSN	0092-0606
DOIs	https://doi.org/10.1007/s10867-009-9156-x
Publication status	Published - 2009

Keywords

Astrocyte
Tripartite synapse
Modeling
Neuron
Calcium waves

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abstract = "We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.",

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AU - Postnov, D.E.

AU - Koreshkov, R.N.

AU - Brazhe, N.A.

AU - Brazhe, A.R.

AU - Sosnovtseva, Olga

PY - 2009

Y1 - 2009

N2 - We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

AB - We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

KW - Astrocyte

KW - Tripartite synapse

KW - Modeling

KW - Neuron

KW - Calcium waves

U2 - 10.1007/s10867-009-9156-x

DO - 10.1007/s10867-009-9156-x

M3 - Journal article

VL - 35

SP - 425

EP - 445

JO - Journal of Biological Physics

JF - Journal of Biological Physics

SN - 0092-0606

IS - 4

ER -

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

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Keywords

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