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Abstract
This study presents the uncertainty and sensitivity analysis of a lignocellulosic enzymatic hydrolysis
model considering both model and feed parameters as sources of uncertainty. The dynamic model is
parametrized for accommodating various types of biomass, and different enzymatic complexes, accounting
a large number of parameters. The sensitivity analysis of model predictions with respect to model parameters
is quantified by the delta mean square measure. By ranking the delta mean square, a reduced subset of
parameters is found helping to identify the bottleneck of the model. The uncertainty analysis is carried
for both model parameters and feed composition in order to assess the accuracy of the predictions. First,
the model and feed parameters are sampled by Latin Hypercube Sampling (LHS) and then Monte Carlo
simulations are run with the sampled values. Feed parameters are considered to be affected by nonzero
mean noise because they are determined by a Near Infrared (NIR) instrument. LHS is performed on
2 parameters: the probability of the mean value and the probability of the standard deviation for each
measurement. The Monte Carlo outputs are then analyzed by linear regression and the standardized
regression coefficients (SRC) are computed for identifying the responsible parameters for model outputs
precision. It is found that sugar yields are mostly sensitive to the composition of the enzymatic complex,
and xylooligomers and glucose inhibition. pH is affected mostly by the amount of acetyl groups in the
hemicellulose, while viscosity is sensitive to a few coefficients from its empirical equation.
Original language  English 

Title of host publication  Proceedings of 2014 AIChE Annual Meeting 
Number of pages  11 
Publisher  American Institute of Chemical Engineers 
Publication date  2014 
Publication status  Published  2014 
Event  2014 AIChE Annual Meeting: American Institute of Chemical Engineers  Atlanta Mariott Marquis & Hilton Atlanta, Atlanta, United States Duration: 16 Nov 2014 → 21 Nov 2014 
Conference
Conference  2014 AIChE Annual Meeting: American Institute of Chemical Engineers 

Location  Atlanta Mariott Marquis & Hilton Atlanta 
Country/Territory  United States 
City  Atlanta 
Period  16/11/2014 → 21/11/2014 
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 2 Conference presentations

Dynamic Simulation, Sensitivity and Uncertainty Analysis of a Demonstration Scale Lignocellulosic Enzymatic Hydrolysis Process
Prunescu, R. M. (Speaker)
16 Nov 2014 → 21 Nov 2014Activity: Talks and presentations › Conference presentations

2014 AIChE Annual Meeting: American Institute of Chemical Engineers
Prunescu, R. M. (Speaker)
17 Nov 2014 → 21 Nov 2014Activity: Talks and presentations › Conference presentations