Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

Mads Sloth Vinding, Christoffer Laustsen, Ivan I. Maximov, Lise Vejby Søgaard, Jan Henrik Ardenkjær-Larsen, Niels Chr. Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aimed at 13C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.
Original languageEnglish
JournalJournal of Magnetic Resonance
Volume227
Pages (from-to)57-61
ISSN1090-7807
DOIs
Publication statusPublished - 2013

Keywords

  • 13C
  • DNP
  • MRI
  • Optimal control
  • Pyruvate
  • Metabolomics

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