TY - CHAP
T1 - Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant
AU - Boojari, Mohammad Amin
AU - Perra, Simone
AU - Colombo, Giorgio
AU - Grossi, Matteo
AU - Jones, Mark Nicholas
AU - Udugama, Isuru
AU - Nasab, Morteza Nikkhah
AU - Fakroleslam, Mohammad
AU - Sahlodin, Ali M.
AU - Shojaosadati, Seyed Abbas
AU - Gernaey, Krist V.
AU - Mansouri, Seyed Soheil
PY - 2022
Y1 - 2022
N2 - The application of model-based tools in biopharmaceutical industry is an active area of research to design, control and analysis of existing and future production of new drugs and therapeutics. In this chapter, a reference plant-wide model for production of a biopharmaceutical compound is proposed. It captures the generic process dynamics of a biopharmaceutical process. As such, it is well-suited to use as a test problem to evaluate different processing scenarios in continuous and semi-continuous fermentation processes.
AB - The application of model-based tools in biopharmaceutical industry is an active area of research to design, control and analysis of existing and future production of new drugs and therapeutics. In this chapter, a reference plant-wide model for production of a biopharmaceutical compound is proposed. It captures the generic process dynamics of a biopharmaceutical process. As such, it is well-suited to use as a test problem to evaluate different processing scenarios in continuous and semi-continuous fermentation processes.
U2 - 10.1007/978-3-030-90924-6_12
DO - 10.1007/978-3-030-90924-6_12
M3 - Book chapter
T3 - Springer Optimization and Its Applications
SP - 323
EP - 353
BT - Optimization of Pharmaceutical Processes
PB - Springer
ER -