Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant

Mohammad Amin Boojari, Simone Perra, Giorgio Colombo, Matteo Grossi, Mark Nicholas Jones, Isuru Udugama, Morteza Nikkhah Nasab, Mohammad Fakroleslam, Ali M. Sahlodin, Seyed Abbas Shojaosadati, Krist V. Gernaey, Seyed Soheil Mansouri*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


The application of model-based tools in biopharmaceutical industry is an active area of research to design, control and analysis of existing and future production of new drugs and therapeutics. In this chapter, a reference plant-wide model for production of a biopharmaceutical compound is proposed. It captures the generic process dynamics of a biopharmaceutical process. As such, it is well-suited to use as a test problem to evaluate different processing scenarios in continuous and semi-continuous fermentation processes.
Original languageEnglish
Title of host publicationOptimization of Pharmaceutical Processes
Publication date2022
Publication statusPublished - 2022
SeriesSpringer Optimization and Its Applications


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