Dynamic coronary MR angiography in a pig model with hyperpolarized water

Hans Kasper Wigh Lipsø, Esben Søvsø Szocska Hansen, Rasmus Stilling Tougaard, Christoffer Laustsen, Jan Henrik Ardenkjær-Larsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

95 Downloads (Pure)

Abstract

To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement to allow high-resolution imaging of the coronary arteries. Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals). The MRI images were acquired with a gradient-echo sequence in an oblique slab covering the main left coronary arteries with 0.55 mm in-plane resolution. The acquisition time was 870 ms per frame. A more than 200-fold signal enhancement compared with thermally polarized water at 3 T was obtained. Coronary angiographic images with a signal-to-noise ratio from the left main stem of 269 ± 169 and coronary sharpness from the proximal left anterior descending coronary artery of 0.31 ± 0.086 mm-1 were obtained. Dynamic images were acquired over a 10 s time window. Hyperpolarized water MR angiography of the coronary arteries in a large animal model with high signal-to-noise ratio and high spatial and temporal resolution was obtained. Magn Reson Med, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume80
Issue number3
Pages (from-to)1165-1169
Number of pages5
ISSN0740-3194
DOIs
Publication statusPublished - 2018

Keywords

  • Cardiac perfusion
  • Coronary angiography
  • Dissolution-DNP
  • Hyperpolarization
  • Magnetic resonance angiography

Cite this

Lipsø, Hans Kasper Wigh ; Hansen, Esben Søvsø Szocska ; Tougaard, Rasmus Stilling ; Laustsen, Christoffer ; Ardenkjær-Larsen, Jan Henrik. / Dynamic coronary MR angiography in a pig model with hyperpolarized water. In: Magnetic Resonance in Medicine. 2018 ; Vol. 80, No. 3. pp. 1165-1169.
@article{324f3c0f1b674bf2b036a7eb3664beb2,
title = "Dynamic coronary MR angiography in a pig model with hyperpolarized water",
abstract = "To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement to allow high-resolution imaging of the coronary arteries. Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals). The MRI images were acquired with a gradient-echo sequence in an oblique slab covering the main left coronary arteries with 0.55 mm in-plane resolution. The acquisition time was 870 ms per frame. A more than 200-fold signal enhancement compared with thermally polarized water at 3 T was obtained. Coronary angiographic images with a signal-to-noise ratio from the left main stem of 269 ± 169 and coronary sharpness from the proximal left anterior descending coronary artery of 0.31 ± 0.086 mm-1 were obtained. Dynamic images were acquired over a 10 s time window. Hyperpolarized water MR angiography of the coronary arteries in a large animal model with high signal-to-noise ratio and high spatial and temporal resolution was obtained. Magn Reson Med, 2018. {\circledC} 2018 International Society for Magnetic Resonance in Medicine.",
keywords = "Cardiac perfusion, Coronary angiography, Dissolution-DNP, Hyperpolarization, Magnetic resonance angiography",
author = "Lips{\o}, {Hans Kasper Wigh} and Hansen, {Esben S{\o}vs{\o} Szocska} and Tougaard, {Rasmus Stilling} and Christoffer Laustsen and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2018",
doi = "10.1002/mrm.27088",
language = "English",
volume = "80",
pages = "1165--1169",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "3",

}

Dynamic coronary MR angiography in a pig model with hyperpolarized water. / Lipsø, Hans Kasper Wigh; Hansen, Esben Søvsø Szocska; Tougaard, Rasmus Stilling; Laustsen, Christoffer; Ardenkjær-Larsen, Jan Henrik.

In: Magnetic Resonance in Medicine, Vol. 80, No. 3, 2018, p. 1165-1169.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Dynamic coronary MR angiography in a pig model with hyperpolarized water

AU - Lipsø, Hans Kasper Wigh

AU - Hansen, Esben Søvsø Szocska

AU - Tougaard, Rasmus Stilling

AU - Laustsen, Christoffer

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2018

Y1 - 2018

N2 - To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement to allow high-resolution imaging of the coronary arteries. Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals). The MRI images were acquired with a gradient-echo sequence in an oblique slab covering the main left coronary arteries with 0.55 mm in-plane resolution. The acquisition time was 870 ms per frame. A more than 200-fold signal enhancement compared with thermally polarized water at 3 T was obtained. Coronary angiographic images with a signal-to-noise ratio from the left main stem of 269 ± 169 and coronary sharpness from the proximal left anterior descending coronary artery of 0.31 ± 0.086 mm-1 were obtained. Dynamic images were acquired over a 10 s time window. Hyperpolarized water MR angiography of the coronary arteries in a large animal model with high signal-to-noise ratio and high spatial and temporal resolution was obtained. Magn Reson Med, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

AB - To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was to achieve large 1 H signal enhancement to allow high-resolution imaging of the coronary arteries. Protons in D2 O were hyperpolarized by dissolution dynamic nuclear polarization. A total of 18 mL of hyperpolarized water was injected into the coronary arteries of healthy pigs (N = 9; 3 injections in 3 animals). The MRI images were acquired with a gradient-echo sequence in an oblique slab covering the main left coronary arteries with 0.55 mm in-plane resolution. The acquisition time was 870 ms per frame. A more than 200-fold signal enhancement compared with thermally polarized water at 3 T was obtained. Coronary angiographic images with a signal-to-noise ratio from the left main stem of 269 ± 169 and coronary sharpness from the proximal left anterior descending coronary artery of 0.31 ± 0.086 mm-1 were obtained. Dynamic images were acquired over a 10 s time window. Hyperpolarized water MR angiography of the coronary arteries in a large animal model with high signal-to-noise ratio and high spatial and temporal resolution was obtained. Magn Reson Med, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

KW - Cardiac perfusion

KW - Coronary angiography

KW - Dissolution-DNP

KW - Hyperpolarization

KW - Magnetic resonance angiography

U2 - 10.1002/mrm.27088

DO - 10.1002/mrm.27088

M3 - Journal article

VL - 80

SP - 1165

EP - 1169

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 3

ER -