Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis

S. Aldi, L. Eriksson, M. Kronqvist, M. Lengquist, Lasse Westergaard Folkersen, L. Perisic, K. H. Grinnemo, J. P. Li, U. Hedin, C. Österholm

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    Abstract

    Vascular intimal calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of heparanase in osteogenesis and bone remodeling is controversial. Previously, we have reported the upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed that the HPSE expression levels correlated with markers of inflammation and increased thrombogenicity.
    Original languageEnglish
    JournalInternational Journal of Experimental Pathology
    Volume98
    Issue number3
    Pages (from-to)A5-A5
    ISSN0959-9673
    Publication statusPublished - 2017
    EventBritish Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell-extracellular matrix communication - St. Catherine's College, Oxford, United Kingdom
    Duration: 3 Apr 20174 Apr 2017
    http://www.bsmb.ac.uk/meetings/bsmb-spring-meeting-3rd-4th-april-2017/

    Conference

    ConferenceBritish Society for Matrix Biology Spring 2017 Meeting
    LocationSt. Catherine's College
    CountryUnited Kingdom
    CityOxford
    Period03/04/201704/04/2017
    Internet address

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