Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis

S. Aldi; L. Eriksson; M. Kronqvist; M. Lengquist; Lasse Westergaard Folkersen; L. Perisic; K. H. Grinnemo; J. P. Li; U. Hedin; C. Österholm

Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis

S. Aldi, L. Eriksson, M. Kronqvist, M. Lengquist, Lasse Westergaard Folkersen, L. Perisic, K. H. Grinnemo, J. P. Li, U. Hedin, C. Österholm

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Abstract

Vascular intimal calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of heparanase in osteogenesis and bone remodeling is controversial. Previously, we have reported the upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed that the HPSE expression levels correlated with markers of inflammation and increased thrombogenicity.

Original language	English
Journal	International Journal of Experimental Pathology
Volume	98
Issue number	3
Pages (from-to)	A5-A5
ISSN	0959-9673
Publication status	Published - 2017
Event	British Society for Matrix Biology Spring 2017 Meeting: Matrix Proteoglycans: active participants in cell-extracellular matrix communication - St. Catherine's College, Oxford, United Kingdom Duration: 3 Apr 2017 → 4 Apr 2017 http://www.bsmb.ac.uk/meetings/bsmb-spring-meeting-3rd-4th-april-2017/

Conference

Conference	British Society for Matrix Biology Spring 2017 Meeting
Location	St. Catherine's College
Country/Territory	United Kingdom
City	Oxford
Period	03/04/2017 → 04/04/2017
Internet address	http://www.bsmb.ac.uk/meetings/bsmb-spring-meeting-3rd-4th-april-2017/

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@article{a9211a6106c34e3983fd14529e52bf8a,

title = "Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis",

abstract = "Vascular intimal calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of heparanase in osteogenesis and bone remodeling is controversial. Previously, we have reported the upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed that the HPSE expression levels correlated with markers of inflammation and increased thrombogenicity.",

author = "S. Aldi and L. Eriksson and M. Kronqvist and M. Lengquist and Folkersen, {Lasse Westergaard} and L. Perisic and Grinnemo, {K. H.} and Li, {J. P.} and U. Hedin and C. {\"O}sterholm",

year = "2017",

language = "English",

volume = "98",

pages = "A5--A5",

journal = "International Journal of Experimental Pathology",

issn = "0959-9673",

publisher = "Wiley-Blackwell",

number = "3",

note = "British Society for Matrix Biology Spring 2017 Meeting : Matrix Proteoglycans: active participants in cell-extracellular matrix communication, BSMB Spring Meeting 2017 ; Conference date: 03-04-2017 Through 04-04-2017",

url = "http://www.bsmb.ac.uk/meetings/bsmb-spring-meeting-3rd-4th-april-2017/",

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TY - JOUR

T1 - Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis

AU - Aldi, S.

AU - Eriksson, L.

AU - Kronqvist, M.

AU - Lengquist, M.

AU - Folkersen, Lasse Westergaard

AU - Perisic, L.

AU - Grinnemo, K. H.

AU - Li, J. P.

AU - Hedin, U.

AU - Österholm, C.

PY - 2017

Y1 - 2017

N2 - Vascular intimal calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of heparanase in osteogenesis and bone remodeling is controversial. Previously, we have reported the upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed that the HPSE expression levels correlated with markers of inflammation and increased thrombogenicity.

AB - Vascular intimal calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of heparanase in osteogenesis and bone remodeling is controversial. Previously, we have reported the upregulation of HPSE in human carotid endarterectomies from symptomatic patients and showed that the HPSE expression levels correlated with markers of inflammation and increased thrombogenicity.

M3 - Journal article

SN - 0959-9673

VL - 98

SP - A5-A5

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

IS - 3

T2 - British Society for Matrix Biology Spring 2017 Meeting

Y2 - 3 April 2017 through 4 April 2017

ER -

Dual roles of heparanase in vascular calcification associated with human carotid atherosclerosis

Abstract

Conference

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