Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

Paolo Marizza; Stephan Sylvest Keller; T. Rades; A. Müllertz; I. Kikic; M. Moneghini; N. De Zordi; D. Solinas; Anja Boisen

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation

Paolo Marizza
, Stephan Sylvest Keller
, T. Rades
, A. Müllertz
, I. Kikic
, M. Moneghini
, N. De Zordi
, D. Solinas
, Anja Boisen

University of Trieste
University of Copenhagen

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

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Abstract

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO₂ impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

Original language	English
Title of host publication	Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society
Number of pages	2
Publication date	2013
Publication status	Published - 2013
Event	40th Annual Meeting & Exposition of the Controlled Release Society - Hawaii Convention Center, Honolulu, Hawaii, United States Duration: 21 Jul 2013 → 24 Jul 2013 Conference number: 40

Conference

Conference	40th Annual Meeting & Exposition of the Controlled Release Society
Number	40
Location	Hawaii Convention Center
Country/Territory	United States
City	Honolulu, Hawaii
Period	21/07/2013 → 24/07/2013

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Cite this

@inbook{fc65ba88e8d74af69d00942c67f14409,

title = "Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation",

abstract = "In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.",

author = "Paolo Marizza and Keller, \{Stephan Sylvest\} and T. Rades and A. M{\"u}llertz and I. Kikic and M. Moneghini and \{De Zordi\}, N. and D. Solinas and Anja Boisen",

year = "2013",

language = "English",

booktitle = "Proceedings of the 40th Annual Meeting \& Exposition of the Controlled Release Society",

note = "40th Annual Meeting \& Exposition of the Controlled Release Society ; Conference date: 21-07-2013 Through 24-07-2013",

}

Marizza, P, Keller, SS, Rades, T, Müllertz, A, Kikic, I, Moneghini, M, De Zordi, N, Solinas, D & Boisen, A 2013, Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation. in Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society. 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, United States, 21/07/2013.

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation. / Marizza, Paolo; Keller, Stephan Sylvest; Rades, T. et al.
Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society. 2013.

Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review

TY - ABST

T1 - Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

AU - Marizza, Paolo

AU - Keller, Stephan Sylvest

AU - Rades, T.

AU - Müllertz, A.

AU - Kikic, I.

AU - Moneghini, M.

AU - De Zordi, N.

AU - Solinas, D.

AU - Boisen, Anja

N1 - Conference code: 40

PY - 2013

Y1 - 2013

N2 - In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

AB - In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

M3 - Conference abstract in proceedings

BT - Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society

T2 - 40th Annual Meeting & Exposition of the Controlled Release Society

Y2 - 21 July 2013 through 24 July 2013

ER -