Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

Paolo Marizza, Stephan Sylvest Keller, T. Rades, A. Müllertz, I. Kikic, M. Moneghini, N. De Zordi, D. Solinas, Anja Boisen

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    Abstract

    In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

    Original languageEnglish
    Title of host publicationProceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society
    Number of pages2
    Publication date2013
    Publication statusPublished - 2013
    Event40th Annual Meeting & Exposition of the Controlled Release Society - Hawaii Convention Center, Honolulu, Hawaii, United States
    Duration: 21 Jul 201324 Jul 2013
    Conference number: 40

    Conference

    Conference40th Annual Meeting & Exposition of the Controlled Release Society
    Number40
    LocationHawaii Convention Center
    CountryUnited States
    CityHonolulu, Hawaii
    Period21/07/201324/07/2013

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