Drug loaded biodegradable polymer microneedles fabricated by hot embossing

Thor Emil Andersen, Alina Joukainen Andersen, Ritika Singh Petersen, Line Hagner Nielsen, Stephan Sylvest Keller*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.
Original languageEnglish
JournalMicroelectronic Engineering
Volume195
Pages (from-to)57-61
ISSN0167-9317
DOIs
Publication statusPublished - 2018

Keywords

  • Microneedles
  • Transdermal
  • Drug delivery
  • Hot embossing
  • Poly‑ε‑caprolactone (PCL)

Cite this

@article{649991df10fe4b8ab21fc5ecaef8fcf4,
title = "Drug loaded biodegradable polymer microneedles fabricated by hot embossing",
abstract = "This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w{\%} gelatine gel without deformation. Finally, PCL MNs containing 20 w/w{\%} of furosemide were fabricated and drug release by diffusion was demonstrated.",
keywords = "Microneedles, Transdermal, Drug delivery, Hot embossing, Poly‑ε‑caprolactone (PCL)",
author = "Andersen, {Thor Emil} and Andersen, {Alina Joukainen} and Petersen, {Ritika Singh} and Nielsen, {Line Hagner} and Keller, {Stephan Sylvest}",
year = "2018",
doi = "10.1016/j.mee.2018.03.024",
language = "English",
volume = "195",
pages = "57--61",
journal = "Microelectronic Engineering",
issn = "0167-9317",
publisher = "Elsevier",

}

Drug loaded biodegradable polymer microneedles fabricated by hot embossing. / Andersen, Thor Emil; Andersen, Alina Joukainen; Petersen, Ritika Singh; Nielsen, Line Hagner; Keller, Stephan Sylvest.

In: Microelectronic Engineering, Vol. 195, 2018, p. 57-61.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Drug loaded biodegradable polymer microneedles fabricated by hot embossing

AU - Andersen, Thor Emil

AU - Andersen, Alina Joukainen

AU - Petersen, Ritika Singh

AU - Nielsen, Line Hagner

AU - Keller, Stephan Sylvest

PY - 2018

Y1 - 2018

N2 - This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

AB - This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

KW - Microneedles

KW - Transdermal

KW - Drug delivery

KW - Hot embossing

KW - Poly‑ε‑caprolactone (PCL)

U2 - 10.1016/j.mee.2018.03.024

DO - 10.1016/j.mee.2018.03.024

M3 - Journal article

VL - 195

SP - 57

EP - 61

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

ER -