Drug loaded biodegradable polymer microneedles fabricated by hot embossing

Thor Emil Andersen; Alina Joukainen Andersen; Ritika Singh Petersen; Line Hagner Nielsen; Stephan Sylvest Keller

doi:10.1016/j.mee.2018.03.024

Drug loaded biodegradable polymer microneedles fabricated by hot embossing

Thor Emil Andersen, Alina Joukainen Andersen, Ritika Singh Petersen, Line Hagner Nielsen, Stephan Sylvest Keller^*

^*Corresponding author for this work

Technical University of Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

Original language	English
Journal	Microelectronic Engineering
Volume	195
Pages (from-to)	57-61
ISSN	0167-9317
DOIs	https://doi.org/10.1016/j.mee.2018.03.024
Publication status	Published - 2018

Keywords

Microneedles
Transdermal
Drug delivery
Hot embossing
Poly‑ε‑caprolactone (PCL)

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10.1016/j.mee.2018.03.024

Andersen Microneedles revisedAccepted author manuscript, 424 KBLicence: CC BY-NC-ND

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title = "Drug loaded biodegradable polymer microneedles fabricated by hot embossing",

abstract = "This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.",

keywords = "Microneedles, Transdermal, Drug delivery, Hot embossing, Poly‑ε‑caprolactone (PCL)",

author = "Andersen, {Thor Emil} and Andersen, {Alina Joukainen} and Petersen, {Ritika Singh} and Nielsen, {Line Hagner} and Keller, {Stephan Sylvest}",

year = "2018",

doi = "10.1016/j.mee.2018.03.024",

language = "English",

volume = "195",

pages = "57--61",

journal = "Microelectronic Engineering",

issn = "0167-9317",

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TY - JOUR

T1 - Drug loaded biodegradable polymer microneedles fabricated by hot embossing

AU - Andersen, Thor Emil

AU - Andersen, Alina Joukainen

AU - Petersen, Ritika Singh

AU - Nielsen, Line Hagner

AU - Keller, Stephan Sylvest

PY - 2018

Y1 - 2018

N2 - This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

AB - This study demonstrates a fast low temperature method for fabrication of drug loaded polymer microneedles (MNs). First, arrays of tapered pillar MNs with a length of 275 ± 3 μm (mean ± SD) and a diameter of 84 ± 1 μm were fabricated in Si with a three-step deep reactive ion etching (DRIE) process. The Si MNs were used as a template for fabrication of polydimethylsiloxane (PDMS) stamps. The stamps were applied for replication of the MNs in spin coated poly‑ε‑caprolactone (PCL) films by hot embossing at 60 °C and a pressure of 1.4 MPa for 3 min. The resulting PCL MNs perfectly resembled the Si MNs and had a length of 270 ± 5 μm and a diameter of 84 ± 3 μm. The MNs had sufficient mechanical strength to penetrate the surface of a 10 w/w% gelatine gel without deformation. Finally, PCL MNs containing 20 w/w% of furosemide were fabricated and drug release by diffusion was demonstrated.

KW - Microneedles

KW - Transdermal

KW - Drug delivery

KW - Hot embossing

KW - Poly‑ε‑caprolactone (PCL)

U2 - 10.1016/j.mee.2018.03.024

DO - 10.1016/j.mee.2018.03.024

M3 - Journal article

SN - 0167-9317

VL - 195

SP - 57

EP - 61

JO - Microelectronic Engineering

JF - Microelectronic Engineering

ER -

Drug loaded biodegradable polymer microneedles fabricated by hot embossing

Abstract

Keywords

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