Drug delivery by phospholipase A(2) degradable liposomes

Jesper Davidsen, C. Vermehren, S. Frøkjær, Ole G. Mouritsen, Kent Jørgensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The effect of poly(ethylene glycol)-phospholipid (PE-PEG) lipopolymers on phospholipase A(2) (PLA(2)) hydrolysis of liposomes composed of stearoyl-oleoylphosphatidylcholine (SOPC) was investigated. The PLA(2) lag-time, which is inversely related to the enzymatic activity, was determined by fluorescence, and the zeta-potentials of the liposomes were measured as a function of PE-PEG lipopolymer concentration. A significant decrease in the lag-time, and hence an increase in enzymatic activity, was observed with increasing amounts of the negatively charged PE-PEG lipopolymers incorporated into the SOPC liposomes. The enhancement of the PLA(2) enzymatic activity might involve a stronger PLA(2) binding affinity towards the negatively charged and polymer covered PEG liposomes.
Original languageEnglish
JournalINTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume214
Issue number1-2
Pages (from-to)67-69
ISSN0378-5173
Publication statusPublished - 2001

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