Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

Lars Linderoth; Günther H.j. Peters; Robert Madsen; Thomas Lars Andresen

doi:10.1002/anie.200805241

Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.

Original language	English
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	10
Pages (from-to)	1823-1826
Number of pages	4
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.200805241
Publication status	Published - 2009

Keywords

Cyclization
Prodrugs
Liposomes
Drug delivery
Phospholipase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200805241

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title = "Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties",

abstract = "Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.",

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AU - Madsen, Robert

AU - Andresen, Thomas Lars

PY - 2009

Y1 - 2009

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AB - Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.

KW - Cyclization

KW - Prodrugs

KW - Liposomes

KW - Drug delivery

KW - Phospholipase

U2 - 10.1002/anie.200805241

DO - 10.1002/anie.200805241

M3 - Journal article

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ER -

Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

Abstract

Keywords

UN SDGs

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