Drug-delivering bacteria

Morten Otto Alexander Sommer (Inventor), Kira Sarup-Lytzen (Inventor), Mareike Bongers (Inventor), Ruben Vazquez Uribe (Inventor), Max Van 'T Hof (Inventor), Frederik Bartholdy Flensmark Neergaard (Inventor), Felipe Gonzalo Tueros Farfan (Inventor), Susanne Kammler (Inventor)

Research output: Patent

31 Downloads (Pure)


The invention relates to a bacterium deficient in at least two functional genes in the redox pathway; or at least one functional gene in the vitamin B1 synthetic pathway and at least one functional gene in the vitamin B6 pathway. The invention also relates to the bacterium comprising an expression cassette for producing a therapeutic molecule. The invention also relates to a kit with the bacterium and a plasmid; as well as a pharmaceutical formulation comprising the bacterium. The invention also relates to use of the bacterium as a medicament, for example for treating Parkinson's disease.

Original languageEnglish
IPCC12N 9/ 12 A I
Patent numberWO2023175124
Filing date08/12/2022
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date08/12/2022
Priority numberEP20220212368
Publication statusPublished - 21 Sept 2023


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