Drug-delivering bacteria

Morten Otto Alexander Sommer; Kira Sarup-Lytzen; Mareike Bongers; Ruben Vazquez Uribe; Max Van 'T Hof; Frederik Bartholdy Flensmark Neergaard; Felipe Gonzalo Tueros Farfan; Susanne Kammler

Drug-delivering bacteria

Morten Otto Alexander Sommer (Inventor), Kira Sarup-Lytzen (Inventor), Mareike Bongers (Inventor), Ruben Vazquez Uribe (Inventor), Max Van 'T Hof (Inventor), Frederik Bartholdy Flensmark Neergaard (Inventor), Felipe Gonzalo Tueros Farfan (Inventor), Susanne Kammler (Inventor)

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Abstract

The invention relates to a bacterium deficient in at least two functional genes in the redox pathway; or at least one functional gene in the vitamin B1 synthetic pathway and at least one functional gene in the vitamin B6 pathway. The invention also relates to the bacterium comprising an expression cassette for producing a therapeutic molecule. The invention also relates to a kit with the bacterium and a plasmid; as well as a pharmaceutical formulation comprising the bacterium. The invention also relates to use of the bacterium as a medicament, for example for treating Parkinson's disease.

Original language	English
IPC	C12N 9/ 12 A I
Patent number	WO2023175124
Filing date	08/12/2022
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	08/12/2022
Priority number	EP20220212368
Publication status	Published - 21 Sept 2023

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title = "Drug-delivering bacteria",

abstract = "The invention relates to a bacterium deficient in at least two functional genes in the redox pathway; or at least one functional gene in the vitamin B1 synthetic pathway and at least one functional gene in the vitamin B6 pathway. The invention also relates to the bacterium comprising an expression cassette for producing a therapeutic molecule. The invention also relates to a kit with the bacterium and a plasmid; as well as a pharmaceutical formulation comprising the bacterium. The invention also relates to use of the bacterium as a medicament, for example for treating Parkinson's disease.",

author = "Sommer, {Morten Otto Alexander} and Kira Sarup-Lytzen and Mareike Bongers and Uribe, {Ruben Vazquez} and {Van 'T Hof}, Max and Neergaard, {Frederik Bartholdy Flensmark} and {Tueros Farfan}, {Felipe Gonzalo} and Susanne Kammler",

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T1 - Drug-delivering bacteria

AU - Sommer, Morten Otto Alexander

AU - Sarup-Lytzen, Kira

AU - Bongers, Mareike

AU - Uribe, Ruben Vazquez

AU - Van 'T Hof, Max

AU - Neergaard, Frederik Bartholdy Flensmark

AU - Tueros Farfan, Felipe Gonzalo

AU - Kammler, Susanne

PY - 2023/9/21

Y1 - 2023/9/21

N2 - The invention relates to a bacterium deficient in at least two functional genes in the redox pathway; or at least one functional gene in the vitamin B1 synthetic pathway and at least one functional gene in the vitamin B6 pathway. The invention also relates to the bacterium comprising an expression cassette for producing a therapeutic molecule. The invention also relates to a kit with the bacterium and a plasmid; as well as a pharmaceutical formulation comprising the bacterium. The invention also relates to use of the bacterium as a medicament, for example for treating Parkinson's disease.

AB - The invention relates to a bacterium deficient in at least two functional genes in the redox pathway; or at least one functional gene in the vitamin B1 synthetic pathway and at least one functional gene in the vitamin B6 pathway. The invention also relates to the bacterium comprising an expression cassette for producing a therapeutic molecule. The invention also relates to a kit with the bacterium and a plasmid; as well as a pharmaceutical formulation comprising the bacterium. The invention also relates to use of the bacterium as a medicament, for example for treating Parkinson's disease.

M3 - Patent

M1 - WO2023175124

Y2 - 2022/12/08

ER -

Drug-delivering bacteria

Abstract

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