Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, Qi Zhao, Jennifer R. Wortman, Shelby L. Bidwell, U. Cecilia M. Alsmark, Sebastien Besteiro, Thomas Sicheritz-Pontén, Christophe J. Noel, Joel B. Dacks, Peter G. Foster, Cedric Simillion, Yves Van de Peer, Diego Miranda-Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke MuellerDaniele Dessi, Pier Luigi Fiori, Qinghu Ren, Ian Paulsen, Hanbang Zhang, Felix D. Bastida-Corcuera, Augusto Simoes-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Y. Okymura, Rachel Schneider, Alias J. Smith, Stepanka Vanacova, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry R. Utterback, Chung-Li Shu, Kazutoyo Osoegawa, Pieter J. de Jong, Ivan Hrdy, Lenka Horvathova, Zuzana Zubacova, Shehre-Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca L. Dunne, Jacqueline A. Upcroft, Peter Upcroft, Owen White, Steven L. Salzberg, Petrus Tang, Cheng-Hsun Chiu, Ying-Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser-Liggett, Patricia J. Johnson

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
    Original languageEnglish
    JournalScience
    Issue number5809
    Pages (from-to)207-12
    ISSN0036-8075
    DOIs
    Publication statusPublished - 2007

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