Does serotonin influence aggression? Comparing regional activity before and during social interaction

C.H. Summers, W.J. Korzan, J.L. Lukkes, M.J. Watt, G.L. Forster, Ø. Øverli, Erik Höglund, E.T. Larson, P.J. Ronan, J.M. Matter, T.R. Summers, K.J. Renner, N. Greenberg

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Abstract

Serotonin is widely believed to exert inhibitory control over aggressive behavior and intent. In addition, a number of studies of fish, reptiles, and mammals, including the lizard Anolis carolinensis, have demonstrated that serotonergic activity is stimulated by aggressive social interaction in both dominant and subordinate males. As serotonergic activity does not appear to inhibit agonistic behavior during combative social interaction, we investigated the possibility that the negative correlation between serotonergic activity and aggression exists before aggressive behavior begins. To do this, putatively dominant and more aggressive males were determined by their speed overcoming stress ( latency to feeding after capture) and their celerity to court females. Serotonergic activities before aggression are differentiated by social rank in a region-specific manner. Among aggressive males baseline serotonergic activity is lower in the septum, nucleus accumbens, striatum, medial amygdala, anterior hypothalamus, raphe, and locus ceruleus but not in the hippocampus, lateral amygdala, preoptic area, substantia nigra, or ventral tegmental area. However, in regions such as the nucleus accumbens, where low serotonergic activity may help promote aggression, agonistic behavior also stimulates the greatest rise in serotonergic activity among the most aggressive males, most likely as a result of the stress associated with social interaction.
Original languageEnglish
JournalPhysiological and Biochemical Zoology
Volume78
Issue number5
Pages (from-to)679-694
ISSN1522-2152
DOIs
Publication statusPublished - 2005
EventSymposium on Integration of Behaviour and Physiology held at the Annual Meeting of the Society-for-Experimental-Biology - Heriot-Watt University, Edinburgh, United Kingdom
Duration: 29 Mar 20042 Apr 2004

Conference

ConferenceSymposium on Integration of Behaviour and Physiology held at the Annual Meeting of the Society-for-Experimental-Biology
LocationHeriot-Watt University
CountryUnited Kingdom
CityEdinburgh
Period29/03/200402/04/2004

Cite this

Summers, C. H., Korzan, W. J., Lukkes, J. L., Watt, M. J., Forster, G. L., Øverli, Ø., ... Greenberg, N. (2005). Does serotonin influence aggression? Comparing regional activity before and during social interaction. Physiological and Biochemical Zoology, 78(5), 679-694. https://doi.org/10.1086/432139
Summers, C.H. ; Korzan, W.J. ; Lukkes, J.L. ; Watt, M.J. ; Forster, G.L. ; Øverli, Ø. ; Höglund, Erik ; Larson, E.T. ; Ronan, P.J. ; Matter, J.M. ; Summers, T.R. ; Renner, K.J. ; Greenberg, N. / Does serotonin influence aggression? Comparing regional activity before and during social interaction. In: Physiological and Biochemical Zoology. 2005 ; Vol. 78, No. 5. pp. 679-694.
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title = "Does serotonin influence aggression? Comparing regional activity before and during social interaction",
abstract = "Serotonin is widely believed to exert inhibitory control over aggressive behavior and intent. In addition, a number of studies of fish, reptiles, and mammals, including the lizard Anolis carolinensis, have demonstrated that serotonergic activity is stimulated by aggressive social interaction in both dominant and subordinate males. As serotonergic activity does not appear to inhibit agonistic behavior during combative social interaction, we investigated the possibility that the negative correlation between serotonergic activity and aggression exists before aggressive behavior begins. To do this, putatively dominant and more aggressive males were determined by their speed overcoming stress ( latency to feeding after capture) and their celerity to court females. Serotonergic activities before aggression are differentiated by social rank in a region-specific manner. Among aggressive males baseline serotonergic activity is lower in the septum, nucleus accumbens, striatum, medial amygdala, anterior hypothalamus, raphe, and locus ceruleus but not in the hippocampus, lateral amygdala, preoptic area, substantia nigra, or ventral tegmental area. However, in regions such as the nucleus accumbens, where low serotonergic activity may help promote aggression, agonistic behavior also stimulates the greatest rise in serotonergic activity among the most aggressive males, most likely as a result of the stress associated with social interaction.",
author = "C.H. Summers and W.J. Korzan and J.L. Lukkes and M.J. Watt and G.L. Forster and {\O}. {\O}verli and Erik H{\"o}glund and E.T. Larson and P.J. Ronan and J.M. Matter and T.R. Summers and K.J. Renner and N. Greenberg",
year = "2005",
doi = "10.1086/432139",
language = "English",
volume = "78",
pages = "679--694",
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Summers, CH, Korzan, WJ, Lukkes, JL, Watt, MJ, Forster, GL, Øverli, Ø, Höglund, E, Larson, ET, Ronan, PJ, Matter, JM, Summers, TR, Renner, KJ & Greenberg, N 2005, 'Does serotonin influence aggression? Comparing regional activity before and during social interaction', Physiological and Biochemical Zoology, vol. 78, no. 5, pp. 679-694. https://doi.org/10.1086/432139

Does serotonin influence aggression? Comparing regional activity before and during social interaction. / Summers, C.H.; Korzan, W.J.; Lukkes, J.L.; Watt, M.J.; Forster, G.L.; Øverli, Ø.; Höglund, Erik; Larson, E.T.; Ronan, P.J.; Matter, J.M.; Summers, T.R.; Renner, K.J.; Greenberg, N.

In: Physiological and Biochemical Zoology, Vol. 78, No. 5, 2005, p. 679-694.

Research output: Contribution to journalConference articleResearchpeer-review

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T1 - Does serotonin influence aggression? Comparing regional activity before and during social interaction

AU - Summers, C.H.

AU - Korzan, W.J.

AU - Lukkes, J.L.

AU - Watt, M.J.

AU - Forster, G.L.

AU - Øverli, Ø.

AU - Höglund, Erik

AU - Larson, E.T.

AU - Ronan, P.J.

AU - Matter, J.M.

AU - Summers, T.R.

AU - Renner, K.J.

AU - Greenberg, N.

PY - 2005

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N2 - Serotonin is widely believed to exert inhibitory control over aggressive behavior and intent. In addition, a number of studies of fish, reptiles, and mammals, including the lizard Anolis carolinensis, have demonstrated that serotonergic activity is stimulated by aggressive social interaction in both dominant and subordinate males. As serotonergic activity does not appear to inhibit agonistic behavior during combative social interaction, we investigated the possibility that the negative correlation between serotonergic activity and aggression exists before aggressive behavior begins. To do this, putatively dominant and more aggressive males were determined by their speed overcoming stress ( latency to feeding after capture) and their celerity to court females. Serotonergic activities before aggression are differentiated by social rank in a region-specific manner. Among aggressive males baseline serotonergic activity is lower in the septum, nucleus accumbens, striatum, medial amygdala, anterior hypothalamus, raphe, and locus ceruleus but not in the hippocampus, lateral amygdala, preoptic area, substantia nigra, or ventral tegmental area. However, in regions such as the nucleus accumbens, where low serotonergic activity may help promote aggression, agonistic behavior also stimulates the greatest rise in serotonergic activity among the most aggressive males, most likely as a result of the stress associated with social interaction.

AB - Serotonin is widely believed to exert inhibitory control over aggressive behavior and intent. In addition, a number of studies of fish, reptiles, and mammals, including the lizard Anolis carolinensis, have demonstrated that serotonergic activity is stimulated by aggressive social interaction in both dominant and subordinate males. As serotonergic activity does not appear to inhibit agonistic behavior during combative social interaction, we investigated the possibility that the negative correlation between serotonergic activity and aggression exists before aggressive behavior begins. To do this, putatively dominant and more aggressive males were determined by their speed overcoming stress ( latency to feeding after capture) and their celerity to court females. Serotonergic activities before aggression are differentiated by social rank in a region-specific manner. Among aggressive males baseline serotonergic activity is lower in the septum, nucleus accumbens, striatum, medial amygdala, anterior hypothalamus, raphe, and locus ceruleus but not in the hippocampus, lateral amygdala, preoptic area, substantia nigra, or ventral tegmental area. However, in regions such as the nucleus accumbens, where low serotonergic activity may help promote aggression, agonistic behavior also stimulates the greatest rise in serotonergic activity among the most aggressive males, most likely as a result of the stress associated with social interaction.

U2 - 10.1086/432139

DO - 10.1086/432139

M3 - Conference article

VL - 78

SP - 679

EP - 694

JO - Physiological and Biochemical Zoology

JF - Physiological and Biochemical Zoology

SN - 1522-2152

IS - 5

ER -