Do very small adipocytes in subcutaneous adipose tissue (a proposed risk factor for insulin insensitivity) have a fetal origin?

Mette Olaf Nielsen; Lei Hou; Lærke Johnsen; Prabhat Khanal; Cecilie Leidesdorff Bechshøft; Anna Hauntoft Kongsted; Allan Vaag; Lars Hellgren

doi:10.1016/j.yclnex.2016.05.003

Do very small adipocytes in subcutaneous adipose tissue (a proposed risk factor for insulin insensitivity) have a fetal origin?

Mette Olaf Nielsen, Lei Hou, Lærke Johnsen, Prabhat Khanal, Cecilie Leidesdorff Bechshøft, Anna Hauntoft Kongsted, Allan Vaag, Lars Hellgren

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Abstract

Previous studies have shown that fetal life malnutrition affects preferences for fat deposition in the body thereby predisposing for visceral adipocity and associated disorders in glucose-insulin regulation. In this study, we aimed to test the hypotheses that late-gestation undernutrition 1) has long-term differential impacts on development, expandability and metabolic features in subcutaneous as compared to perirenal and mesenteric adipose tissues, which 2) will predispose for visceral obesity upon exposure to an obesogenic diet in early postnatal life.

Original language	English
Journal	Clinical Nutrition Experimental
Volume	8
Pages (from-to)	9-24
Number of pages	16
DOIs	https://doi.org/10.1016/j.yclnex.2016.05.003
Publication status	Published - 2016

Bibliographical note

© 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

Fetal programming
Subcutaneous expandability
Visceral obesity
Mesenteric fat
Perirenal fat
Fatty acid composition

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10.1016/j.yclnex.2016.05.003

Do very small adipocytes in subcutaneous adipose tissueFinal published version, 3.02 MBLicence: CC BY-NC-ND

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Cite this

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title = "Do very small adipocytes in subcutaneous adipose tissue (a proposed risk factor for insulin insensitivity) have a fetal origin?",

abstract = "Previous studies have shown that fetal life malnutrition affects preferences for fat deposition in the body thereby predisposing for visceral adipocity and associated disorders in glucose-insulin regulation. In this study, we aimed to test the hypotheses that late-gestation undernutrition 1) has long-term differential impacts on development, expandability and metabolic features in subcutaneous as compared to perirenal and mesenteric adipose tissues, which 2) will predispose for visceral obesity upon exposure to an obesogenic diet in early postnatal life.",

keywords = "Fetal programming, Subcutaneous expandability, Visceral obesity, Mesenteric fat, Perirenal fat, Fatty acid composition",

author = "Nielsen, {Mette Olaf} and Lei Hou and L{\ae}rke Johnsen and Prabhat Khanal and Bechsh{\o}ft, {Cecilie Leidesdorff} and Kongsted, {Anna Hauntoft} and Allan Vaag and Lars Hellgren",

note = "{\textcopyright} 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

year = "2016",

doi = "10.1016/j.yclnex.2016.05.003",

language = "English",

volume = "8",