Do very small adipocytes in subcutaneous adipose tissue (a proposed risk factor for insulin insensitivity) have a fetal origin?

Mette Olaf Nielsen, Lei Hou, Lærke Johnsen, Prabhat Khanal, Cecilie Leidesdorff Bechshøft, Anna Hauntoft Kongsted, Allan Vaag, Lars Hellgren

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    Abstract

    Previous studies have shown that fetal life malnutrition affects preferences for fat deposition in the body thereby predisposing for visceral adipocity and associated disorders in glucose-insulin regulation. In this study, we aimed to test the hypotheses that late-gestation undernutrition 1) has long-term differential impacts on development, expandability and metabolic features in subcutaneous as compared to perirenal and mesenteric adipose tissues, which 2) will predispose for visceral obesity upon exposure to an obesogenic diet in early postnatal life.
    Original languageEnglish
    JournalClinical Nutrition Experimental
    Volume8
    Pages (from-to)9-24
    Number of pages16
    ISSN2352-9393
    DOIs
    Publication statusPublished - 2016

    Bibliographical note

    © 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

    Keywords

    • Fetal programming
    • Subcutaneous expandability
    • Visceral obesity
    • Mesenteric fat
    • Perirenal fat
    • Fatty acid composition

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