Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software

Birgit Sander, Hajer Ahmad Al-Abiji, Mads Kofod, Thomas Martini Jørgensen

Research output: Contribution to journalJournal articleResearchpeer-review

282 Downloads (Pure)

Abstract

Purpose
Spectral-domain optical coherence tomographies (OCTs) from different companies do not give identical retinal thicknesses. The purpose of this study was to evaluate if differences in thickness when using a spectral domain Cirrus OCT or a Heidelberg Spectralis are due to hardware differences,or if they are caused by the segmentation algorithms.

Methods
Thirty-seven healthy eyes were examined within the same session with a Cirrus OCT and a Spectralis OCT, the latter using averaged B-scans. Scans from similar positions and passing the fovea were analyzed by custom-made software. Thickness was analyzed at the fovea, the central 1-mmline and the 6-mm line.

Results
When Cirrus and Spectralis scans were analyzed with the same software, the retinal thickness at the foveal center was 225.92 μm (SD 17.0) using the Cirrus and 228.70 μm(SD 18.4) using the Spectralis; the difference of 2.78 μm wasnot significant (p=0.055). For the central 1 mm, the difference was 1.78 μm (p=0.0414), and for all points out to 6 mm, the Spectralis retinal thickness was also significantly larger than the Cirrus thickness (p=0.0052), though the mean difference was only 1.85 μm. Also for the RPE_OScomplex, Spectralis measured a greater thickness than did Cirrus, with a mean of3.32 μm (p<0.0001) for all points.

Conclusion
The retinal thicknesses from the Cirrus and from the Spectralis differed by 14 μm with the standard software of the instruments, and by less than 3 μm when analyzed with the same custom-made software, indicating that the major differences between the two SD-OCT systems are due to differences in their built-in software algorithms.
Original languageEnglish
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume253
Issue number11
Pages (from-to)1915-1921
ISSN0721-832X
DOIs
Publication statusPublished - 2015

Keywords

  • OCT
  • Spectral domain
  • Retinal thickness
  • Outer segments
  • Segmentation

Fingerprint

Dive into the research topics of 'Do different spectral domain OCT hardwares measure the same? Comparison of retinal thickness using third-party software'. Together they form a unique fingerprint.

Cite this