TY - JOUR
T1 - Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
AU - Sørensen, Christoffer V.
AU - Knudsen, Cecilie
AU - auf dem Keller, Ulrich
AU - Kalogeropoulos, Konstantinos
AU - Gutiérrez-Jiménez, Cristina
AU - Pucca, Manuela Berto
AU - Arantes, Eliane C.
AU - Bordon, Karla C. F.
AU - Laustsen, Andreas H.
PY - 2020
Y1 - 2020
N2 - Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination.
AB - Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination.
KW - Snakebite envenoming
KW - Venom
KW - Antibiotics
KW - Snake venom serine proteases
KW - Snake venom metalloproteases
KW - Infection
KW - Drug-toxin interactions
U2 - 10.3390/toxins12040240
DO - 10.3390/toxins12040240
M3 - Journal article
C2 - 32283690
SN - 2072-6651
VL - 12
JO - Toxins
JF - Toxins
IS - 4
M1 - 240
ER -