Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?

Christoffer V. Sørensen, Cecilie Knudsen, Ulrich auf dem Keller, Konstantinos Kalogeropoulos, Cristina Gutiérrez-Jiménez, Manuela Berto Pucca, Eliane C. Arantes, Karla C. F. Bordon, Andreas H. Laustsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleCommunication

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Abstract

Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination.
Original languageEnglish
Article number240
JournalToxins
Volume12
Issue number4
Number of pages6
ISSN2072-6651
DOIs
Publication statusPublished - 2020

Keywords

  • Snakebite envenoming
  • Venom
  • Antibiotics
  • Snake venom serine proteases
  • Snake venom metalloproteases
  • Infection
  • Drug-toxin interactions

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