@inbook{b809f0ec8648484ba3b31e6c5c196d66,
title = "Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems",
abstract = "Biologically active small molecules can be identified through the screening of compound libraries. Traditionally, such libraries were composed of large numbers of structurally similar compounds. However, it is now widely acknowledged that library size is not everything; the structural diversity of the library is crucial. Structurally diverse small molecule libraries should contain compounds with a broad range of biological activities, which are capable of providing compounds active against a variety of biological targets. Diversity-oriented synthesis (DOS) seeks to generate structurally diverse small-molecule libraries in an efficient manner. Here, we discuss the general principles of DOS. A case study describing the discovery of new small-molecule modulators of mitosis using DOS illustrates the utility of this approach in the identification of new biologically relevant chemical entities.",
author = "Galloway, {Warren R. J. D.} and David Wilcke and Feilin Nie and Kathy Hadje-Georgiou and Luca Laraia and Spring, {David R.}",
year = "2014",
doi = "10.1002/9783527687503.ch26",
language = "English",
isbn = "9783527336111",
series = "Concepts and Case Studies in Chemical Biology",
pages = "379--389",
editor = "Waldmann, {H. } and Janning, {P. }",
booktitle = "Concepts and Case Studies in Chemical Biology",
publisher = "Wiley-VCH",
address = "Germany",
}