Diversity and functions of intestinal mononuclear phagocytes

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

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Diversity and functions of intestinal mononuclear phagocytes. / Joeris, Thorsten; Müller-Luda, K; Agace, William Winston; Mowat, A McI.

In: Mucosal Immunology, Vol. 10, No. 4, 2017, p. 845-864.

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

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Joeris, Thorsten ; Müller-Luda, K ; Agace, William Winston ; Mowat, A McI. / Diversity and functions of intestinal mononuclear phagocytes. In: Mucosal Immunology. 2017 ; Vol. 10, No. 4. pp. 845-864.

Bibtex

@article{c6211b3970ef4d6b8da0ace8a42dec0f,
title = "Diversity and functions of intestinal mononuclear phagocytes",
abstract = "The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for ‘fine tuning’ immunological responses within the intestine, a process that maybe of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.",
author = "Thorsten Joeris and K M{\"u}ller-Luda and Agace, {William Winston} and Mowat, {A McI}",
year = "2017",
doi = "10.1038/mi.2017.22",
language = "English",
volume = "10",
pages = "845--864",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Diversity and functions of intestinal mononuclear phagocytes

AU - Joeris, Thorsten

AU - Müller-Luda, K

AU - Agace, William Winston

AU - Mowat, A McI

PY - 2017

Y1 - 2017

N2 - The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for ‘fine tuning’ immunological responses within the intestine, a process that maybe of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

AB - The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for ‘fine tuning’ immunological responses within the intestine, a process that maybe of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.

U2 - 10.1038/mi.2017.22

DO - 10.1038/mi.2017.22

M3 - Journal article

VL - 10

SP - 845

EP - 864

JO - Mucosal Immunology

JF - Mucosal Immunology

SN - 1933-0219

IS - 4

ER -