Diversity and functions of intestinal mononuclear phagocytes

Thorsten Joeris, K Müller-Luda, William Winston Agace, A McI Mowat

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    Abstract

    The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for ‘fine tuning’ immunological responses within the intestine, a process that maybe of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.
    Original languageEnglish
    JournalMucosal Immunology
    Volume10
    Issue number4
    Pages (from-to)845-864
    ISSN1933-0219
    DOIs
    Publication statusPublished - 2017

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