Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

Ling Ding; Armin Maier; Heinz-Herbert Fiebig; Helmar Goerls; Wen-Han Lin; Gundela Peschel; Christian Hertweck

doi:10.1002/anie.201006165

Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

Ling Ding
, Armin Maier
, Heinz-Herbert Fiebig
, Helmar Goerls
, Wen-Han Lin
, Gundela Peschel
, Christian Hertweck

Research output: Contribution to journal › Journal article › Communication

Abstract

In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.

Original language	English
Journal	Angewandte chemie-international edition
Volume	50
Issue number	7
Pages (from-to)	1630-1634
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201006165
Publication status	Published - 2011
Externally published	Yes

Access to Document

10.1002/anie.201006165

OpenUrl availability

Full text

Cite this

@article{17c7e369ae5f4ca4b83347126480754a,

title = "Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis",

abstract = "In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties. ",

author = "Ling Ding and Armin Maier and Heinz-Herbert Fiebig and Helmar Goerls and Wen-Han Lin and Gundela Peschel and Christian Hertweck",

year = "2011",

doi = "10.1002/anie.201006165",

language = "English",

volume = "50",

pages = "1630--1634",

journal = "Angewandte chemie-international edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

AU - Ding, Ling

AU - Maier, Armin

AU - Fiebig, Heinz-Herbert

AU - Goerls, Helmar

AU - Lin, Wen-Han

AU - Peschel, Gundela

AU - Hertweck, Christian

PY - 2011

Y1 - 2011

N2 - In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.

AB - In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.

U2 - 10.1002/anie.201006165

DO - 10.1002/anie.201006165

M3 - Journal article

SN - 1433-7851

VL - 50

SP - 1630

EP - 1634

JO - Angewandte chemie-international edition

JF - Angewandte chemie-international edition

IS - 7

ER -

Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this