In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.
Ding, L., Maier, A., Fiebig, H-H., Goerls, H., Lin, W-H., Peschel, G., & Hertweck, C. (2011). Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis. Angewandte chemie-international edition, 50(7), 1630-1634. https://doi.org/10.1002/anie.201006165