Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Helmar Goerls, Wen-Han Lin, Gundela Peschel, Christian Hertweck

Research output: Contribution to journalJournal articleCommunication

Abstract

In-built diversification: Four ansa macrolides, divergolidesa A-D (1-4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties. 
Original languageEnglish
JournalAngewandte chemie-international edition
Volume50
Issue number7
Pages (from-to)1630-1634
Number of pages5
ISSN1433-7851
DOIs
Publication statusPublished - 2011
Externally publishedYes

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