Abstract
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group- assisted decarboxylation.
| Original language | English |
|---|---|
| Journal | Organic and Biomolecular Chemistry |
| Volume | 13 |
| Issue number | 6 |
| Pages (from-to) | 1618-1623 |
| Number of pages | 6 |
| ISSN | 1477-0520 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |