TY - JOUR
T1 - Distinct immune phenotypes in infants developing asthma during childhood
AU - Thysen, Anna Hammerich
AU - Waage, Johannes
AU - Larsen, Jeppe Madura
AU - Rasmussen, Morten Arendt
AU - Stokholm, Jakob
AU - Chawes, Bo
AU - Fink, Nadia Rahman
AU - Pedersen, Tine Marie
AU - Wolsk, Helene
AU - Thorsteinsdottir, Sunna
AU - Litman, Thomas
AU - Renz, Harald
AU - Bønnelykke, Klaus
AU - Bisgaard, Hans
AU - Brix, Susanne
PY - 2020
Y1 - 2020
N2 - Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.
AB - Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent disease at 6 years of age. An abnormal neutrophil-linked antiviral response was associated with increased risk of transient asthma. Children who exhibited persistent asthma at year 6 showed enhanced interleukin-5 (IL-5) and IL-13 production in stimulated T cells at 18 months of age, which was associated with early life bacterial colonization of the airways. These findings highlight the early appearance of distinct immune characteristics in infants developing different asthma endotypes during childhood.
U2 - 10.1126/scitranslmed.aaw0258
DO - 10.1126/scitranslmed.aaw0258
M3 - Journal article
C2 - 32024797
SN - 1946-6234
VL - 12
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 529
M1 - eaaw0258
ER -