Dissolution Dynamic Nuclear Polarization capability study with fluid path

Ronja Maja Malinowski, Hans Kasper Wigh Lipsø, Mathilde Hauge Lerche, Jan Henrik Ardenkjær-Larsen

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Abstract

Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer. In this study, we present a method of filling the fluid path that allows it to be reused. The filling method has been investigated in terms of reproducibility at two extrema, high dose for patient use and low dose for rodent studies, using [1-13C]pyruvate as example. We demonstrate that the filling method allows high reproducibility of six quality control parameters with standard deviations 3–10 times smaller than the acceptance criteria intervals in clinical studies.
Original languageEnglish
JournalJournal of Magnetic Resonance
Volume272
Pages (from-to)141-146
ISSN1090-7807
DOIs
Publication statusPublished - 2016

Keywords

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics
  • Dissolution-DNP
  • Dynamic Nuclear Polarization
  • Hyperpolarization
  • Polarizer
  • Dissolution
  • Filling
  • Magnetic resonance
  • Optical instruments
  • Spin polarization
  • Acceptance criteria
  • Dissolution DNP
  • Dissolution dynamics
  • Dynamic nuclear polarization
  • High reproducibility
  • Standard deviation
  • Polarization

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