Dissipation and effects of chlortetracycline and tylosin in two agricultural soils: A field-scale study in southern Denmark

Bent Halling-Sørensen, Anne-Marie Jacobsen, John Jensen, Gitte Sengeløv, Eivira Vaclavik, Flemming Ingerslev

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Presently, there is a basic lack of information concerning the accumulation of antibacterial agent residues in agricultural soils. In this field study, performed in southern Denmark, we assess the dissipation of chlortetracycline (CTC), and tylosin A (TYL A) as a function of time. Field soils were classified as a sandy loam soil (field A) and a sandy soil (field 13) and each field was sampled on six occasions during the 155-d experimental period from May to October 2000 for chemical analysis and counts of colony-forming units (CFU) detecting the level of aerobic bacteria surviving antibiotic exposure. Colony-forming units and TYL A were detected throughout the entire sampling period, with respective starting soil concentrations of 30 and 50 mu g kg(-1) soil declining to 1 and 5 mu g kg(-1) soil, on day 155. Compound half-lives (95% confidence limits in parentheses) were estimated for both fields and T-1/2 for CTC was 25 d (20-34) and 34 d (28-42) in fields A and B, respectively, and T-1/2 for TYL A was 67 d (54-86) and 49 d (40-64) in fields A and B, respectively. No significant difference was determined between compound half-lives on the two fields. The level of aerobic antibiotic-resistant bacteria in the soil over time and soil fauna community was assessed in relation to application of manure containing antibacterial agents to the agricultural fields. The level of both CTC- and TYL-resistant bacteria was affected in the soil by amendment of manure, but declined during the study to the same level as observed at the beginning.
    Original languageEnglish
    JournalEnvironmental Toxicology and Chemistry
    Volume24
    Issue number4
    Pages (from-to)802-810
    ISSN0730-7268
    DOIs
    Publication statusPublished - 2005

    Keywords

    • tylosin
    • field study
    • antibacterial agents
    • chlortetracycline
    • dissipation

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