DisProt in 2022:  improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia; Bálint Mészáros; Edoardo Salladini; András Hatos; Rita Pancsa; Lucía B Chemes; Mátyás Pajkos; Tamas Lazar; Samuel Peña-Díaz; Jaime Santos; Veronika Ács; Nazanin Farahi; Erzsébet Fichó; Maria Cristina Aspromonte; Claudio Bassot; Anastasia Chasapi; Norman E. Davey; Radoslav Davidović; Laszlo Dobson; Arne Elofsson; Gábor Erdős; Pascale Gaudet; Michelle Giglio; Juliana Glavina; Javier Iserte; Valentín Iglesias; Zsófia Kálmán; Matteo Lambrughi; Emanuela Leonardi; Sonia Longhi; Sandra Macedo-Ribeiro; Emiliano Maiani; Julia Marchetti; Cristina Marino-Buslje; Attila Mészáros; Alexander Miguel Monzon; Giovanni Minervini; Suvarna Nadendla; Juliet F. Nilsson; Marian Novotný; Christos A. Ouzounis; Nicolás Palopoli; Elena Papaleo; Pedro José Barbosa Pereira; Gabriele Pozzati; Vasilis J. Promponas; Jordi Pujols; Alma Carolina Sanchez Rocha; Martin Salas; Luciana Rodriguez Sawicki; Eva Schad; Aditi Shenoy; Tamás Szaniszló; Konstantinos D. Tsirigos; Nevena Veljkovic; Gustavo Parisi; Salvador Ventura; Zsuzsanna Dosztányi; Peter Tompa; Silvio C.E. Tosatto; Damiano Piovesan

doi:10.1093/nar/gkab1082

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucía B Chemes, Mátyás Pajkos, Tamas Lazar, Samuel Peña-Díaz, Jaime Santos, Veronika Ács, Nazanin Farahi, Erzsébet Fichó, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E. Davey, Radoslav Davidović, Laszlo Dobson, Arne ElofssonGábor Erdős, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentín Iglesias, Zsófia Kálmán, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino-Buslje, Attila Mészáros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F. Nilsson, Marian Novotný, Christos A. Ouzounis, Nicolás Palopoli, Elena Papaleo, Pedro José Barbosa Pereira, Gabriele Pozzati, Vasilis J. Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamás Szaniszló, Konstantinos D. Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C.E. Tosatto, Damiano Piovesan^*

^*Corresponding author for this work

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Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Original language	English
Journal	Nucleic acids research
Volume	50
Issue number	D1
Pages (from-to)	D480–D487
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gkab1082
Publication status	Published - 2022

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Quaglia, F., Mészáros, B., Salladini, E., Hatos, A., Pancsa, R., Chemes, L. B., Pajkos, M., Lazar, T., Peña-Díaz, S., Santos, J., Ács, V., Farahi, N., Fichó, E., Aspromonte, M. C., Bassot, C., Chasapi, A., Davey, N. E., Davidović, R., Dobson, L., ... Piovesan, D. (2022). DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic acids research, 50(D1), D480–D487. https://doi.org/10.1093/nar/gkab1082

Quaglia, Federica ; Mészáros, Bálint ; Salladini, Edoardo ; Hatos, András ; Pancsa, Rita ; Chemes, Lucía B ; Pajkos, Mátyás ; Lazar, Tamas ; Peña-Díaz, Samuel ; Santos, Jaime ; Ács, Veronika ; Farahi, Nazanin ; Fichó, Erzsébet ; Aspromonte, Maria Cristina ; Bassot, Claudio ; Chasapi, Anastasia ; Davey, Norman E. ; Davidović, Radoslav ; Dobson, Laszlo ; Elofsson, Arne ; Erdős, Gábor ; Gaudet, Pascale ; Giglio, Michelle ; Glavina, Juliana ; Iserte, Javier ; Iglesias, Valentín ; Kálmán, Zsófia ; Lambrughi, Matteo ; Leonardi, Emanuela ; Longhi, Sonia ; Macedo-Ribeiro, Sandra ; Maiani, Emiliano ; Marchetti, Julia ; Marino-Buslje, Cristina ; Mészáros, Attila ; Monzon, Alexander Miguel ; Minervini, Giovanni ; Nadendla, Suvarna ; Nilsson, Juliet F. ; Novotný, Marian ; Ouzounis, Christos A. ; Palopoli, Nicolás ; Papaleo, Elena ; Pereira, Pedro José Barbosa ; Pozzati, Gabriele ; Promponas, Vasilis J. ; Pujols, Jordi ; Rocha, Alma Carolina Sanchez ; Salas, Martin ; Sawicki, Luciana Rodriguez ; Schad, Eva ; Shenoy, Aditi ; Szaniszló, Tamás ; Tsirigos, Konstantinos D. ; Veljkovic, Nevena ; Parisi, Gustavo ; Ventura, Salvador ; Dosztányi, Zsuzsanna ; Tompa, Peter ; Tosatto, Silvio C.E. ; Piovesan, Damiano. / DisProt in 2022 : improved quality and accessibility of protein intrinsic disorder annotation. In: Nucleic acids research. 2022 ; Vol. 50, No. D1. pp. D480–D487.

@article{90efe69f6e394345bdb3feda183913b7,

title = "DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation",

abstract = "The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.",

author = "Federica Quaglia and B{\'a}lint M{\'e}sz{\'a}ros and Edoardo Salladini and Andr{\'a}s Hatos and Rita Pancsa and Chemes, {Luc{\'i}a B} and M{\'a}ty{\'a}s Pajkos and Tamas Lazar and Samuel Pe{\~n}a-D{\'i}az and Jaime Santos and Veronika {\'A}cs and Nazanin Farahi and Erzs{\'e}bet Fich{\'o} and Aspromonte, {Maria Cristina} and Claudio Bassot and Anastasia Chasapi and Davey, {Norman E.} and Radoslav Davidovi{\'c} and Laszlo Dobson and Arne Elofsson and G{\'a}bor Erd{\H o}s and Pascale Gaudet and Michelle Giglio and Juliana Glavina and Javier Iserte and Valent{\'i}n Iglesias and Zs{\'o}fia K{\'a}lm{\'a}n and Matteo Lambrughi and Emanuela Leonardi and Sonia Longhi and Sandra Macedo-Ribeiro and Emiliano Maiani and Julia Marchetti and Cristina Marino-Buslje and Attila M{\'e}sz{\'a}ros and Monzon, {Alexander Miguel} and Giovanni Minervini and Suvarna Nadendla and Nilsson, {Juliet F.} and Marian Novotn{\'y} and Ouzounis, {Christos A.} and Nicol{\'a}s Palopoli and Elena Papaleo and Pereira, {Pedro Jos{\'e} Barbosa} and Gabriele Pozzati and Promponas, {Vasilis J.} and Jordi Pujols and Rocha, {Alma Carolina Sanchez} and Martin Salas and Sawicki, {Luciana Rodriguez} and Eva Schad and Aditi Shenoy and Tam{\'a}s Szaniszl{\'o} and Tsirigos, {Konstantinos D.} and Nevena Veljkovic and Gustavo Parisi and Salvador Ventura and Zsuzsanna Doszt{\'a}nyi and Peter Tompa and Tosatto, {Silvio C.E.} and Damiano Piovesan",

year = "2022",

doi = "10.1093/nar/gkab1082",

language = "English",

volume = "50",

pages = "D480–D487",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "D1",

}

Quaglia, F, Mészáros, B, Salladini, E, Hatos, A, Pancsa, R, Chemes, LB, Pajkos, M, Lazar, T, Peña-Díaz, S, Santos, J, Ács, V, Farahi, N, Fichó, E, Aspromonte, MC, Bassot, C, Chasapi, A, Davey, NE, Davidović, R, Dobson, L, Elofsson, A, Erdős, G, Gaudet, P, Giglio, M, Glavina, J, Iserte, J, Iglesias, V, Kálmán, Z, Lambrughi, M, Leonardi, E, Longhi, S, Macedo-Ribeiro, S, Maiani, E, Marchetti, J, Marino-Buslje, C, Mészáros, A, Monzon, AM, Minervini, G, Nadendla, S, Nilsson, JF, Novotný, M, Ouzounis, CA, Palopoli, N, Papaleo, E, Pereira, PJB, Pozzati, G, Promponas, VJ, Pujols, J, Rocha, ACS, Salas, M, Sawicki, LR, Schad, E, Shenoy, A, Szaniszló, T, Tsirigos, KD, Veljkovic, N, Parisi, G, Ventura, S, Dosztányi, Z, Tompa, P, Tosatto, SCE & Piovesan, D 2022, 'DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation', Nucleic acids research, vol. 50, no. D1, pp. D480–D487. https://doi.org/10.1093/nar/gkab1082

DisProt in 2022 : improved quality and accessibility of protein intrinsic disorder annotation. / Quaglia, Federica; Mészáros, Bálint; Salladini, Edoardo; Hatos, András; Pancsa, Rita; Chemes, Lucía B; Pajkos, Mátyás; Lazar, Tamas; Peña-Díaz, Samuel; Santos, Jaime; Ács, Veronika; Farahi, Nazanin; Fichó, Erzsébet; Aspromonte, Maria Cristina; Bassot, Claudio; Chasapi, Anastasia; Davey, Norman E.; Davidović, Radoslav; Dobson, Laszlo; Elofsson, Arne; Erdős, Gábor; Gaudet, Pascale; Giglio, Michelle; Glavina, Juliana; Iserte, Javier; Iglesias, Valentín; Kálmán, Zsófia; Lambrughi, Matteo; Leonardi, Emanuela; Longhi, Sonia; Macedo-Ribeiro, Sandra; Maiani, Emiliano; Marchetti, Julia; Marino-Buslje, Cristina; Mészáros, Attila; Monzon, Alexander Miguel; Minervini, Giovanni; Nadendla, Suvarna; Nilsson, Juliet F.; Novotný, Marian; Ouzounis, Christos A.; Palopoli, Nicolás; Papaleo, Elena; Pereira, Pedro José Barbosa; Pozzati, Gabriele; Promponas, Vasilis J.; Pujols, Jordi; Rocha, Alma Carolina Sanchez; Salas, Martin; Sawicki, Luciana Rodriguez; Schad, Eva; Shenoy, Aditi; Szaniszló, Tamás; Tsirigos, Konstantinos D.; Veljkovic, Nevena; Parisi, Gustavo; Ventura, Salvador; Dosztányi, Zsuzsanna; Tompa, Peter; Tosatto, Silvio C.E.; Piovesan, Damiano.

In: Nucleic acids research, Vol. 50, No. D1, 2022, p. D480–D487.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - DisProt in 2022

T2 - improved quality and accessibility of protein intrinsic disorder annotation

AU - Quaglia, Federica

AU - Mészáros, Bálint

AU - Salladini, Edoardo

AU - Hatos, András

AU - Pancsa, Rita

AU - Chemes, Lucía B

AU - Pajkos, Mátyás

AU - Lazar, Tamas

AU - Peña-Díaz, Samuel

AU - Santos, Jaime

AU - Ács, Veronika

AU - Farahi, Nazanin

AU - Fichó, Erzsébet

AU - Aspromonte, Maria Cristina

AU - Bassot, Claudio

AU - Chasapi, Anastasia

AU - Davey, Norman E.

AU - Davidović, Radoslav

AU - Dobson, Laszlo

AU - Elofsson, Arne

AU - Erdős, Gábor

AU - Gaudet, Pascale

AU - Giglio, Michelle

AU - Glavina, Juliana

AU - Iserte, Javier

AU - Iglesias, Valentín

AU - Kálmán, Zsófia

AU - Lambrughi, Matteo

AU - Leonardi, Emanuela

AU - Longhi, Sonia

AU - Macedo-Ribeiro, Sandra

AU - Maiani, Emiliano

AU - Marchetti, Julia

AU - Marino-Buslje, Cristina

AU - Mészáros, Attila

AU - Monzon, Alexander Miguel

AU - Minervini, Giovanni

AU - Nadendla, Suvarna

AU - Nilsson, Juliet F.

AU - Novotný, Marian

AU - Ouzounis, Christos A.

AU - Palopoli, Nicolás

AU - Papaleo, Elena

AU - Pereira, Pedro José Barbosa

AU - Pozzati, Gabriele

AU - Promponas, Vasilis J.

AU - Pujols, Jordi

AU - Rocha, Alma Carolina Sanchez

AU - Salas, Martin

AU - Sawicki, Luciana Rodriguez

AU - Schad, Eva

AU - Shenoy, Aditi

AU - Szaniszló, Tamás

AU - Tsirigos, Konstantinos D.

AU - Veljkovic, Nevena

AU - Parisi, Gustavo

AU - Ventura, Salvador

AU - Dosztányi, Zsuzsanna

AU - Tompa, Peter

AU - Tosatto, Silvio C.E.

AU - Piovesan, Damiano

PY - 2022

Y1 - 2022

N2 - The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

AB - The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

U2 - 10.1093/nar/gkab1082

DO - 10.1093/nar/gkab1082

M3 - Journal article

C2 - 34850135

VL - 50

SP - D480–D487

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

ER -

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

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