Feared for its highly neurotoxic venom and rapid attack technique, the Black mamba (Dendroaspis polylepis) is Africa’s largest venomous snake. The clinical manifestations of a bitefrom D. polylepis include flaccid paralysis leading to respiratory failure and death due to postsynaptic blockade of the neuromuscular junctions caused by α-neurotoxins. Since antivenoms suffer from a reactivity bias towards larger toxins due the fact that antivenoms areproduced by immunization of large mammals, current antivenoms could be reinforced by additionof monoclonal antitoxins directed towards the smaller α-neurotoxins. Here, we report the discovery of selective nanobodies targeting α-elapitoxin Dpp2c from D. polylepis through phage display screening.
|Number of pages||1|
|Publication status||Published - 2015|
|Event||12th Protein.DTU Workshop - Kgs. Lyngby , Denmark|
Duration: 17 Apr 2015 → 17 Apr 2015
|Workshop||12th Protein.DTU Workshop|
|Period||17/04/2015 → 17/04/2015|