Discovery of Selective Nanobodies against α-elapitoxin Dpp2c from Black Mamba through Phage Display Screening

Christina Milbo, Andreas Hougaard Laustsen, Brian Lohse

    Research output: Contribution to conferencePosterResearchpeer-review

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    Abstract

    Feared for its highly neurotoxic venom and rapid attack technique, the Black mamba (Dendroaspis polylepis) is Africa’s largest venomous snake. The clinical manifestations of a bitefrom D. polylepis include flaccid paralysis leading to respiratory failure and death due to postsynaptic blockade of the neuromuscular junctions caused by α-neurotoxins. Since antivenoms suffer from a reactivity bias towards larger toxins due the fact that antivenoms areproduced by immunization of large mammals, current antivenoms could be reinforced by additionof monoclonal antitoxins directed towards the smaller α-neurotoxins. Here, we report the discovery of selective nanobodies targeting α-elapitoxin Dpp2c from D. polylepis through phage display screening.
    Original languageEnglish
    Publication date2015
    Number of pages1
    Publication statusPublished - 2015
    Event12th Protein.DTU Workshop - Kgs. Lyngby , Denmark
    Duration: 17 Apr 201517 Apr 2015

    Workshop

    Workshop12th Protein.DTU Workshop
    CountryDenmark
    CityKgs. Lyngby
    Period17/04/201517/04/2015

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