Discovery of Peptide-based Inhibitors against Dendrotoxin B from Black Mamba through Phage Display Screening

Saioa O. Cob, Andreas Munk, Andreas Hougaard Laustsen

    Research output: Contribution to conferencePosterResearchpeer-review

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    Abstract

    The black mamba (Dendroaspis polylepis) is Africa’s most feared snake due to its potent, rapidacting venom and its speed of attack. The most abundant toxins in D. polylepis venom are the Kunitz-type proteinase inhibitors, dendrotoxins, which are unique for mamba. Dendrotoxinsare poorly neutralized by current antivenoms, and they are almost impossible to raise an immune response against due to their similarity to homologous mammalian, non-toxic proteins. Here,we report the discovery of peptide-based antitoxins against dendrotoxin B from D. polylepis through phage display screening.
    Original languageEnglish
    Publication date2015
    Number of pages1
    Publication statusPublished - 2015
    Event12th Protein.DTU Workshop - Kgs. Lyngby , Denmark
    Duration: 17 Apr 201517 Apr 2015

    Workshop

    Workshop12th Protein.DTU Workshop
    Country/TerritoryDenmark
    CityKgs. Lyngby
    Period17/04/201517/04/2015

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