Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy

Thomas Ostenfeld Larsen; Bent O. Petersen; Jens Øllgaard Duus; Dan  Sørensen; Jens Christian Frisvad; Michael Edberg Hansen

Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy

Thomas Ostenfeld Larsen
, Bent O. Petersen
, Jens Øllgaard Duus
, Dan Sørensen
, Jens Christian Frisvad
, Michael Edberg Hansen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1)andB(2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.

Original language	English
Journal	Journal of Natural Products
Volume	68
Pages (from-to)	871-874
ISSN	0163-3864
Publication status	Published - 2005

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Science/technology

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title = "Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy",

abstract = "X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1)andB(2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.",

keywords = "Science/technology",

author = "Larsen, \{Thomas Ostenfeld\} and Petersen, \{Bent O.\} and Duus, \{Jens {\O}llgaard\} and Dan S{\o}rensen and Frisvad, \{Jens Christian\} and Hansen, \{Michael Edberg\}",

year = "2005",

language = "English",

volume = "68",

pages = "871--874",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy. / Larsen, Thomas Ostenfeld; Petersen, Bent O.; Duus, Jens Øllgaard et al.
In: Journal of Natural Products, Vol. 68, 2005, p. 871-874.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy

AU - Larsen, Thomas Ostenfeld

AU - Petersen, Bent O.

AU - Duus, Jens Øllgaard

AU - Sørensen, Dan

AU - Frisvad, Jens Christian

AU - Hansen, Michael Edberg

PY - 2005

Y1 - 2005

N2 - X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1)andB(2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.

AB - X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1)andB(2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.

KW - Science/technology

M3 - Journal article

SN - 0163-3864

VL - 68

SP - 871

EP - 874

JO - Journal of Natural Products

JF - Journal of Natural Products

ER -

Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy

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