Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV-spectra, combined with structural determination by NMR spectroscophy

Thomas Ostenfeld Larsen, Bent O. Petersen, Jens Øllgaard Duus, Dan Sørensen, Jens Christian Frisvad, Michael Edberg Hansen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    X-hitting, a newly developed algorithm for automated comparison of UV data, has been used for the tracking of two novel spiro-quinazoline metabolites, lapatins A (1)andB(2), in a screening study targeting quinazolines. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, primarily 2D NMR.
    Original languageEnglish
    JournalJournal of Natural Products
    Volume68
    Pages (from-to)871-874
    ISSN0163-3864
    Publication statusPublished - 2005

    Keywords

    • Science/technology

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