Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera

Christoffer V. Sørensen*, José R. Almeida, Markus-Frederik Bohn, Esperanza Rivera de Torre, Sanne Schoffelen, Bjørn G. Voldborg, Anne Ljungars, Sakthivel Vaiyapuri*, Andreas H. Laustsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Despite the considerable global impact of snakebite envenoming, available treatments remain suboptimal. Here, we report the discovery of a broadly-neutralizing human monoclonal antibody, using a phage display-based cross-panning strategy, capable of reducing the cytotoxic effects of venom phospholipase A2s from three different snake genera from different continents. This highlights the potential of utilizing monoclonal antibodies to develop more effective, safer, and globally accessible polyvalent antivenoms that can be widely used to treat snakebite envenoming.
Original languageEnglish
Article number107307
JournalToxicon
Volume234
Number of pages5
ISSN0041-0101
DOIs
Publication statusPublished - 2023

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