Discovery and optimization of peptide-based anti-cobratoxins

M. Sola; Andreas Hougaard Laustsen; J. Johannesen; T. Lynagh; Mads Hartvig Clausen; B. Lohse

Discovery and optimization of peptide-based anti-cobratoxins

M. Sola , Andreas Hougaard Laustsen, J. Johannesen, T. Lynagh, Mads Hartvig Clausen, B. Lohse

Department of Chemistry

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Abstract

More than 5.5 million people per year are victims of snake envenomation, resulting in 125,000 deaths and 400,000amputations worldwide. Antivenoms are still produced by animal immunization procedures, and they areassociated with a high risk of severe adverse reactions. Alternatively, synthetic peptides may open the possibility for newtherapies with better efficacy and safety. Here, we report the discovery and optimization of a synthetic peptide directedagainst α-cobratoxin (α-CTX), the most toxic component of Monocled cobra (Naja kaouthia).

Original language	English
Publication date	2015
Number of pages	1
Publication status	Published - 2015
Event	Symposium for Biological and Life Science Students (SymBLS) 2015 - Cambridge, United Kingdom Duration: 6 Nov 2015 → 6 Nov 2015

Conference

Conference	Symposium for Biological and Life Science Students (SymBLS) 2015
Country/Territory	United Kingdom
City	Cambridge
Period	06/11/2015 → 06/11/2015

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title = "Discovery and optimization of peptide-based anti-cobratoxins",

abstract = "More than 5.5 million people per year are victims of snake envenomation, resulting in 125,000 deaths and 400,000amputations worldwide. Antivenoms are still produced by animal immunization procedures, and they areassociated with a high risk of severe adverse reactions. Alternatively, synthetic peptides may open the possibility for newtherapies with better efficacy and safety. Here, we report the discovery and optimization of a synthetic peptide directedagainst α-cobratoxin (α-CTX), the most toxic component of Monocled cobra (Naja kaouthia).",

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note = "Symposium for Biological and Life Science Students (SymBLS) 2015, SymBLS 2015 ; Conference date: 06-11-2015 Through 06-11-2015",

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T1 - Discovery and optimization of peptide-based anti-cobratoxins

AU - Sola , M.

AU - Laustsen, Andreas Hougaard

AU - Johannesen, J.

AU - Lynagh, T.

AU - Clausen, Mads Hartvig

AU - Lohse, B.

PY - 2015

Y1 - 2015

N2 - More than 5.5 million people per year are victims of snake envenomation, resulting in 125,000 deaths and 400,000amputations worldwide. Antivenoms are still produced by animal immunization procedures, and they areassociated with a high risk of severe adverse reactions. Alternatively, synthetic peptides may open the possibility for newtherapies with better efficacy and safety. Here, we report the discovery and optimization of a synthetic peptide directedagainst α-cobratoxin (α-CTX), the most toxic component of Monocled cobra (Naja kaouthia).

AB - More than 5.5 million people per year are victims of snake envenomation, resulting in 125,000 deaths and 400,000amputations worldwide. Antivenoms are still produced by animal immunization procedures, and they areassociated with a high risk of severe adverse reactions. Alternatively, synthetic peptides may open the possibility for newtherapies with better efficacy and safety. Here, we report the discovery and optimization of a synthetic peptide directedagainst α-cobratoxin (α-CTX), the most toxic component of Monocled cobra (Naja kaouthia).

M3 - Poster

T2 - Symposium for Biological and Life Science Students (SymBLS) 2015

Y2 - 6 November 2015 through 6 November 2015

ER -

Discovery and optimization of peptide-based anti-cobratoxins

Abstract

Conference

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