Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Chris Breward; Jane Heffernan; Miura Robert M.; Neal Madras; John Ockendon; Mads Peter Sørensen; Robert Anderssen; Roderick Melnik; Mark McGuinness; Sanjive Qazi

Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Chris Breward (Author), Jane Heffernan (Author), Miura Robert M. (Author), Neal Madras (Author), John Ockendon (Author), Mads Peter Sørensen (Author), Robert Anderssen (Author), Roderick Melnik (Author), Mark McGuinness (Author), Sanjive Qazi (Author)

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Abstract

The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.

Original language	English
Publication date	2008
Publication status	Published - 2008
Event	Fields-MITACS Industrial Problem-Solving Workshop - University of Toronto, Canada, 11-15 August, 2008. Duration: 1 Jan 2008 → …

Conference

Conference	Fields-MITACS Industrial Problem-Solving Workshop
City	University of Toronto, Canada, 11-15 August, 2008.
Period	01/01/2008 → …

Keywords

HIV therapies
Nonlinear models of bio systems
Inflamatory pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.",

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A2 - Sørensen, Mads Peter

A2 - Anderssen, Robert

A2 - Melnik, Roderick

A2 - McGuinness, Mark

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AB - The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.

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M3 - Sound/Visual production (digital)

T2 - Fields-MITACS Industrial Problem-Solving Workshop

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Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Abstract

Conference

Keywords

UN SDGs

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