Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Chris Breward (Author), Jane Heffernan (Author), Miura Robert M. (Author), Neal Madras (Author), John Ockendon (Author), Mads Peter Sørensen (Author), Robert Anderssen (Author), Roderick Melnik (Author), Mark McGuinness (Author), Sanjive Qazi (Author)

    Research output: Non-textual formSound/Visual production (digital)Research

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    Abstract

    The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.
    Original languageEnglish
    Publication date2008
    Publication statusPublished - 2008
    Event2008 Fields-MITACS Industrial Problem-Solving Workshop - University of Toronto, Fields Institute, 222 College Street, Toronto, Canada
    Duration: 11 Aug 200815 Aug 2008

    Workshop

    Workshop2008 Fields-MITACS Industrial Problem-Solving Workshop
    LocationUniversity of Toronto, Fields Institute, 222 College Street
    Country/TerritoryCanada
    CityToronto
    Period11/08/200815/08/2008

    Keywords

    • HIV therapies
    • Nonlinear models of bio systems
    • Inflamatory pathway

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