Discovery and Assesment of New Target Sites for Anti-HIV Therapies

Chris Breward (Author), Jane Heffernan (Author), Miura Robert M. (Author), Neal Madras (Author), John Ockendon (Author), Mads Peter Sørensen (Author), Robert Anderssen (Author), Roderick Melnik (Author), Mark McGuinness (Author), Sanjive Qazi (Author)

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    The HIV viruses infect cells by endocytosis and takes over parts of the cells reaction pathways in order to reproduce itself and spread the infection. One such pathway is the mammalian inflammatory signaling, which invoke NF-κB as the principal transcription factor. A treatment against HIV could be based on blocking the NF-κB pathway by a suitably designed drug. The aim of the current project is to investigate the feasibility of this idea by using mathematical modelling of the NF-κB pathway.
    Original languageEnglish
    Publication date2008
    Publication statusPublished - 2008
    EventFields-MITACS Industrial Problem-Solving Workshop - University of Toronto, Canada, 11-15 August, 2008.
    Duration: 1 Jan 2008 → …


    ConferenceFields-MITACS Industrial Problem-Solving Workshop
    CityUniversity of Toronto, Canada, 11-15 August, 2008.
    Period01/01/2008 → …


    • HIV therapies
    • Nonlinear models of bio systems
    • Inflamatory pathway


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