DISAL glycosyl donors for the synthesis of a linear hexasaccharide under mild conditions

Lars Petersen, Jane B. Laursen, K. Larsen, M.S. Motawia, Knud Jørgen Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The new class of glycosyl donors with a methyl 3,5-dinitrosalicylate (DISAL) anomeric leaving group has proved efficient for glycosylation under strictly neutral, mildly basic, or mildly acidic conditions. Here, we report the synthesis of novel DISAL disaccharide glycosyl donors prepared by easy nucleophilic aromatic substitution. These DISAL donors proved efficient in the synthesis of a starch-related hexasaccharide under very mild conditions. Glycosylations proceeded with alpha-selectivity and were compatible with Trt protecting groups.
Original languageEnglish
JournalORGANIC LETTERS
Volume5
Issue number8
Pages (from-to)1309-1312
ISSN1523-7060
Publication statusPublished - 2003

Fingerprint Dive into the research topics of 'DISAL glycosyl donors for the synthesis of a linear hexasaccharide under mild conditions'. Together they form a unique fingerprint.

Cite this