Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Kritika Kumar, Adrian Nightingale, Siva H. Krishnadasan, Nazila Kamaly, Marzena Wylenzinska-Arridge, Katharina Zeissler, Will R. Branford, Ecaterina Ware, Andrew J. deMello, John C. deMello

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T2 relaxivity of 66 mM−1s−1 at 4.7 T, signifying good MRI contrast enhancement properties.
Original languageEnglish
JournalJournal of Materials Chemistry
Volume22
Issue number11
Pages (from-to)4704-4708
ISSN0959-9428
Publication statusPublished - 2012
Externally publishedYes

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