Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Kritika Kumar; Adrian Nightingale; Siva H. Krishnadasan; Nazila Kamaly; Marzena Wylenzinska-Arridge; Katharina Zeissler; Will R. Branford; Ecaterina Ware; Andrew J.  deMello; John C. deMello

Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Kritika Kumar, Adrian Nightingale, Siva H. Krishnadasan, Nazila Kamaly, Marzena Wylenzinska-Arridge, Katharina Zeissler, Will R. Branford, Ecaterina Ware, Andrew J. deMello, John C. deMello

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T2 relaxivity of 66 mM−1s−1 at 4.7 T, signifying good MRI contrast enhancement properties.

Original language	English
Journal	Journal of Materials Chemistry
Volume	22
Issue number	11
Pages (from-to)	4704-4708
ISSN	0959-9428
Publication status	Published - 2012
Externally published	Yes

OpenUrl availability

Full text

Cite this

@article{166c55f521704abd8bf3b5f63aace36c,

title = "Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor",

abstract = "We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T2 relaxivity of 66 mM−1s−1 at 4.7 T, signifying good MRI contrast enhancement properties.",

author = "Kritika Kumar and Adrian Nightingale and Krishnadasan, {Siva H.} and Nazila Kamaly and Marzena Wylenzinska-Arridge and Katharina Zeissler and Branford, {Will R.} and Ecaterina Ware and deMello, {Andrew J.} and deMello, {John C.}",

year = "2012",

language = "English",

volume = "22",

pages = "4704--4708",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

AU - Kumar, Kritika

AU - Nightingale, Adrian

AU - Krishnadasan, Siva H.

AU - Kamaly, Nazila

AU - Wylenzinska-Arridge, Marzena

AU - Zeissler, Katharina

AU - Branford, Will R.

AU - Ware, Ecaterina

AU - deMello, Andrew J.

AU - deMello, John C.

PY - 2012

Y1 - 2012

N2 - We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T2 relaxivity of 66 mM−1s−1 at 4.7 T, signifying good MRI contrast enhancement properties.

AB - We describe the controlled synthesis of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) using a stable passively-driven capillary-based droplet reactor. High quality highly crystalline particles were obtained with a narrow size distribution of mean diameter 3.6 nm and standard deviation 0.8 nm. The particles were evaluated for use in MRI, and found to exhibit a large saturation magnetisation of 58 emu/g and a high T2 relaxivity of 66 mM−1s−1 at 4.7 T, signifying good MRI contrast enhancement properties.

M3 - Journal article

SN - 0959-9428

VL - 22

SP - 4704

EP - 4708

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 11

ER -

Direct synthesis of dextran-coated superparamagnetic iron oxide nanoparticles in a capillary-based droplet reactor

Abstract

OpenUrl availability

Fingerprint

Cite this